Platelet/Albumin ratio and plateletcrit levels are potential new biomarkers for assessing endoscopic inflammatory bowel disease severity

Table 4 Discriminatory power of each biomarker for endoscopic IBD activity by ROC curves

		AuROC (95% CI)	Cut-off value	Sensitivity	Specificity	Youden’s J statistic
UC	PLT × 10⁹/L	0.687 (0.573, 0.802)	> 286.50	0.491	0.889	0.380^***
	ALB (g/L)	0.654 (0.547, 0.762)	< 34.50	0.546	0.833	0.400^***
	PLT/ALB	0.7050.591, 0.819)	> 5.880	0.787	0.556	0.343^***
	hs-CRP (mg/L)	0.607 (0.497, 0.719)	> 14.750	0.444	0.944	0.389
	ESR (mm/hr)	0.552 (0.428, 0.688)	> 16.50	0.565	0.667	0.231
CD	PLT × 10⁹/L	0.728 (0.615, 0.814)	> 318.5	0.706	0.649	0.355^***
	PCT (%)	0.779 (0.678, 0.860)	> 0.235	0.882	0.571	0.454^***
	PLT/ALB	0.694 (0.575, 0.781)	> 8.823	0.735	0.597	0.333^***
	FIB (g/L)	0.729 (0.626, 0.826)	> 3.840	0.941	0.481	0.422^***
	hs-CRP (mg/L)	0.698 (0.581, 0.786)	> 7.450	0.910	0.390	0.360^***
	ESR (mm/hr)	0.746 (0.640, 0.828)	> 15.50	0.853	0.558	0.411^***

*p < 0.05 was considered statistically significant; **p < 0.01; ***p < 0.005
Low endoscopic disease activity: Mayo 0 or 1 in UC and SES-CD < 10 in CD; High endoscopic disease activity: Mayo 2 or 3 in UC and SES-CD ≥ 10 in CD.
Abbreviations: ROC, Receiver operating characteristics; hs-CRP, high sensitive C-reactive protein; ESR, erythrocyte sedimentation rate; FIB, fibrinogen; PLT, platelet; PCT, plateletcrit; ALB, Albumin; PLT/ALB, platelet-to-albumin ratio

ISSN: 1471-230X