Table 5 Univariate and multivariate cox regression analysis before and after IPTW adjustment in FAH cohort

Age

  < 55

Reference

Reference

Reference

Reference

  > =55

1.73 (0.98–3.06)

0.057

1.62 (0.87–3.05)

0.130

1.36 (0.75–2.46)

0.312

1.48 (0.77–2.83)

0.236

Sex

 Female

Reference

Reference

 Male

1.51 (0.87–2.62)

0.144

1.51 (0.83–2.77)

0.178

PTS

 Stamoch

Reference

Reference

Reference

 Small intestine

0.32 (0.13–0.79)

0.013

0.37 (0.16–0.85)

0.019

0.39 (0.15–1.04)

0.059

 Colorectum

0.54 (0.29–0.99)

0.048

0.44 (0.24–0.83)

0.011

0.38 (0.18–0.82)

0.014

Grade

 Well differentiation G1

Reference

Reference

Reference

Reference

 Moderate differentiation G2

1.40 (0.55–3.6)

0.483

1.42 (0.53–3.78)

0.483

1.35 (0.6–3.03)

0.466

1.57 (0.66–3.72)

0.306

 Poor differentiation G3

3.38 (1.12–10.22)

0.031

2.54 (0.77–8.34)

0.124

1.52 (0.35–6.65)

0.576

1.02 (0.3–3.47)

0.973

 NEC

6.08 (3.6–18.3)

0.001

5.11 (1.51–17.31)

0.009

4.96 (1.53–16.1)

0.008

3.86 (1.1–13.62)

0.036

T

 T1

Reference

Reference

 T2

0.83 (0.35–2)

0.685

0.72 (0.3–1.73)

0.456

 T3

1.46 (0.64–3.32)

0.363

1.07 (0.42–2.7)

0.886

 T4

2.13 (0.95–4.78)

0.066

1.84 (0.86–3.94)

0.117

PTR

 No

Reference

Reference

Reference

Reference

 Yes

0.49 (0.27–0.88)

0.018

0.29 (0.14–0.59)

< 0.001

0.44 (0.25–0.77)

0.005

0.26 (0.13–0.52)

< 0.001

Primary tumor size

  < 2

Reference

Reference

Reference

Reference

  > =2

3.17 (1.35–7.42)

0.008

2.23 (0.93–5.38)

0.073

2.51 (1.05–5.96)

0.038

1.98 (0.82–4.81)

0.131

Extrahepatic metastases

 No

Reference

Reference

Reference

Reference

 Yes

2.5 (1.46–4.28)

< 0.001

2.84 (1.58–5.11)

< 0.001

2.73 (1.55–4.8)

< 0.001

3.35 (1.67–6.72)

< 0.001