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Fig. 2 | BMC Gastroenterology

Fig. 2

From: Integration of single-cell and bulk RNA sequencing to establish a prognostic signature based on tumor-associated macrophages in colorectal cancer

Fig. 2

Identification and functional enrichment of M2RDEGs. (A) A volcano plot shows M2RDEGs that are upregulated (red) or downregulated (green) in M2 clusters between tumor and normal tissues. The top five upregulated genes and top five downregulated genes are labeled. (B) A heatmap shows the top 20 significantly expressed M2RDEGs. (C) GO and KEGG [16] (D) enrichment results of the 80 M2RDEGs. Identification of prognostic signature genes. (E) The forest plot shows the results of univariate cox regression of seven prognostic genes. Genes with Hazard Ratio < 1 were negatively associated with prognosis, and vice versa. (F, G) Lasso COX regression analysis was conducted to identify the best prognostic signature genes for constructing the risk model

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BMC Gastroenterology

ISSN: 1471-230X

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