Table 3 Factors associated with the decision to prescribe VDZ + BUD
Univariate logistic regression model | Odds ratio (95% CI) | p-value (for category) | p-value (for variable) | ||
|---|---|---|---|---|---|
Sex (ref = Male) | Female | 1.55 (0.74, 3.24) | - | 0.2447 | |
Age (ref = > 75 years old) | < 30 years old | 1.78 (0.15, 20.86) | 0.6470 | ||
30–49 years old | 0.97 (0.08, 11.57) | 0.9779 | |||
50–75 years old | 1.47 (0.12, 18.29) | 0.7661 | |||
Weight (ref = < 60 kg) | 60–74 kg | 0.31 (0.11, 0.89) | 0.0288 | ||
> 74 kg | 0.56 (0.20, 1.52) | 0.2530 | |||
Smoking status (ref = Non-smoker) | Former smoker | 0.97 (0.35, 2.74) | 0.9575 | ||
Current smoker | 1.02 (0.45, 2.31) | 0.9726 | |||
Site location (ref = Belgium) | Switzerland | 1.63 (0.63, 4.26) | 0.3147 | ||
Israel | 0.54 (0.16, 1.83) | 0.3234 | |||
Charlson Comorbidity Index | 0.92 (0.71, 1.19) | - | 0.5185 | ||
Number of prior biologics received (ref = 0) | 1 | 0.40 (0.16, 0.98) | 0.0455 | ||
> 1 | 1.56 (0.55, 4.41) | 0.4064 | |||
AP (ref = None) | Mild | 1.75 (0.13, 23.67) | 0.6743 | ||
Moderate | 5.28 (0.62, 44.61) | 0.1266 | |||
Severe | 9.79 (0.90, 106.68) | 0.0612 | |||
LSF | Number | 0.95 (0.84, 1.07) | - | 0.3948 | |
AP/LSF score | Number | 0.98 (0.87, 1.10) | - | 0.7062 | |
Phenotype (ref = Non-stricturing, non-penetrating) | Penetrating | 0.41 (0.08, 2.11) | 0.2858 | ||
Stricturing | 1.43 (0.57, 3.62) | 0.4461 | |||
Location of CD (ref = Ileum) | Colonic | 0.96 (0.33, 2.79) | 0.9323 | ||
Ileocolonic | 1.75 (0.71, 4.32) | 0.2219 | |||
Duration of CD (ref = < 2 years) | ≥ 2 years | 0.45 (0.17, 1.16) | - | 0.0961 | |
Prior CD-related surgery (ref = No) | Yes | 0.76 (0.37, 1.58) | - | 0.4664 | |
Multivariate regression model | |||||
Weight (ref = < 60 kg) | 60–74 kg | 0.28 (0.09–0.91) | 0.0338 | ||
> 74 kg | 0.63 (0.21–1.87) | 0.4044 | |||
Number of prior biologics received (ref = 0) | 1 | 0.39 (0.15–1.03) | 0.0570 | ||
> 1 | 1.01 (0.27–3.71) | 0.9925 | |||