Table 1 Baseline characteristics of the biochemical response in patients with PBC

Sex(female)

223 (86.80)

73 (83.90)

150 (88.20)

0.273

Age (years)

56.20 ± 11.84

55.23 ± 10.97

56.74 ± 12.31

0.336

BMI

22.22 (20.44–24.09)

21.64 (19.56–24.23)

22.60 (20.70–24.23)

0.141

F-UDCA

235 (91.40)

80 (92)

155 (91.20)

0.822

Cirrhosis

83 (31.90)

33 (37.90)

49 (28.80)

0.147

Fatigue

18(7.0%)

8(9.20%)

10(5.90%)

0.439

Pruritus

36(14.0%)

13(14.90%)

23(13.50%)

0.850

Comorbidities

    Hypertension

29 (11.30)

5 (5.75)

24 (14.12)

0.043

    Thyroid disease

50 (19.50)

11 (12.64)

39 (22.94)

0.046

    Atherosis

5 (1.90)

4 (4.60)

1 (0.59)

0.028

Complications

    Esophageal and gastric varices

46 (17.90)

23 (26.44)

23 (13.53)

0.011

    Ascites

39 (15.20)

20 (22.99)

19 (11.18)

0.038

Laboratory date

    Albumin (g/l)

36.90 (32.00–41.35)

33.80 (28.30–38.60)

38.20 (33.60–42.65)

< 0.001

    Globulin (g/l)

35.13 ± 7.70

36.49 ± 7.80

34.45 ± 7.59

0.045

    Total bilirubin (umol/l)

25.00 (15.5–49.30)

36.70 (24.40–70.10)

19.60 (13.60–34.35)

< 0.001

    Alanine aminotransferase (×ULN)

60.00 (32.00–104.00)

75.00 (41.00–103.00)

51.00 (27.00–103.00)

0.019

    Aspartate aminotransferase(×ULN)

69.00 (42.00–117.00)

88.00 (71.00–130.00)

54.00 (35.00–105.00)

0.010

    Alkaline phosphatase (×ULN)

220.00 (132.00–347.50)

395.00 (259.00–549.00)

160.00 (113.00–233.50)

< 0.001

    γ-Glutamyl transferase (×ULN)

206.00 (77.00–421.50)

400.00 (201.00–709.00)

159.00 (49.50–311.00)

< 0.001

    Total cholesterol (mmol/l)

4.83 (3.90–6.06)

57.90 (24.10–170.60)

21.30 (8.35–68.80)

< 0.001

    HDL-C (mmol/l)

1.28 (0.93–1.68)

1.29 (0.85–1.91)

1.26 (0.99–1.64)

0.676

    LDL-C (mmol/l)

2.74 (2.09–3.64)

3.16 (2.32–4.72)

2.54 (1.95–3.33)

< 0.001

    White blood cell (× 10⁹/l)

4.88 (3.59–5.97)

4.85 (3.82–6.39)

4.88 (3.58–5.74)

0.287

    Neutrophil counts (×10⁹/l)

2.75 (1.92–3.65)

2.91 (2.12–4.28)

2.58 (1.89–3.44)

0.017

    Lymphocyte counts (10⁹/l)

1.48 (1.04–1.92)

1.38 (1.03–1.78)

1.53 (1.06–2.05)

0.070

    Monocyte counts (×10⁹/l)

0.31 (0.23–0.40)

0.31 (0.23–0.41)

0.31 (0.24–0.40)

0.885

    NLR

1.83 (1.27–2.76)

2.16 (1.43–3.33)

1.70 (1.18–2.53)

0.001

    Platelet count (×10⁹/l)

150.00 (93.50–225.00)

150.00 (85.00–228.00)

153.00 (95.50–222.00)

0.722

    International normalized ratio

1.05 ()0.95–1.19

1.02 (0.92–1.18)

1.05 (0.97–1.20)

0.076

    APTT(s)

35.80 (31.70–39.70)

37.29 ± 7.29

34.76 ± 6.10

0.004

    Serum creatinine (umol/l)

58.00 (50.00–66.00)

54.00 (46.00–62.00)

60.00 (54.00–66.00)

< 0.001

    Serum sodium (mmol/l)

139.80 (137.73–14,158)

139.10 (137.20–141.00)

140.30 (138.30–142.00)

0.008

    Positive AMA-2

132 (51.40)

49 (56.32)

83 (48.82)

0.274

    SP100

25(9.70)

9(10.34)

16(9.41)

0.823

    GP210

64(24.90)

27(31.03)

37(21.76)

0.110