HBV pregenome RNA as a predictor of spontanous HBeAg seroconversion in HBeAg-positive chronic hepatitis B patients

Table 2 Screening variables for the prediction of spontaneous HBeAg Seroconversion

Variables	Group A (n = 18)	Group B (n = 36)	Student’s t-test P values	Univariate logistic regression P values (OR [95% CI])	Multivariate logistic regression P values (OR [95% CI])	AUROC P values [95% CI]
HBV pgRNA, log₁₀ copies/ml
12 weeks	6.35 ± 1.24	7.52 ± 0.79	0.001	0.002 (3.82 [1.63, 8.94])	0.028 (4.46 [1.18, 16.85])	0.782 (0.001 [0.646, 0.919])
28 weeks	4.74 ± 1.33	7.28 ± 1.14	0.001	0.001 (3.98 [1.99, 7.94])	/	0.912 (0.001 [0.830, 0.994])
∆HBV pgRNA, log₁₀ copies/ml
12 weeks	1.33 ± 1.30	-0.05 ± 0.89	0.001	0.003 (0.24 [0.09, 0.61])	/	0.816 (0.001 [0.699, 0.934])
28 weeks	2.94 ± 1.38	0.19 ± 1.25	0.001	0.001 (0.22 [0.10, 0.49])	0.001 (0.20 [0.08, 0.54])	0.934 (0.001 [0.872, 0.996])

∆HBV pgRNA, the reduction of the level of HBV pgRNA from baseline; AUROC Area under the receiver-operator curve, OR Odd ratio, 95% CI 95% confifidence interval

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