Fig. 4

Immunohistochemical staining of IHCC tissues for 5-LO, and the association between the number of 5-LO-positive cells and FAP expression in the peripheral and intratumoral regions. Staining shows (a) low and (b) high expression of 5-LO (magnification ×400). Bar = 100 μm. (c) The number of 5-LO-positive cells is not significantly different between the groups with high and low FAP expression in the peripheral region. (d) The number of 5-LO-positive cells is significantly higher in the group with high FAP expression in the intratumoral region than the group with low FAP expression in the intratumoral region (p = 0.023). IHCC, intrahepatic cholangiocarcinoma; 5-LO, hyperactivated 5-lipoxygenase; FAP, fibroblast activation protein