Table 4 Univariate and multivariate analyses of risk factors for lymph node metastasis

Age (y)

 ≤60

8 (17.4)

1.000

 >60

6 (6.9)

0.823

0.571–1.186

0.296

Gender (n)

 Male

8 (8.5)

1.000

 Female

6 (15.4)

1.955

0.630–6.063

0.246

Tumor location

0.320

 Cardia and fundus

4 (7.5)

0.784

0.198–3.095

0.728

 Body

5 (18.5)

2.182

0.572–8.319

0.253

 Antrum

5 (9.4)

1.000

Tumor size (cm)

 ≤2.0

5 (8.6)

1.000

 >2.0

9 (12.0)

1.445

0.457–4.572

0.531

Tumor differentiation

0.123

 Differentiated-type

4 (6.0)

1.000

1.000

 Undifferentiated-type

0 (0.0)

0.000

0.999

0.000

0.999

 Mixed-type

10 (18.5)

3.580

1.055–12.15

0.041

2.977

0.810–10.93

0.100

Tumor invasion

 Mucosa (T1a)

4 (8.9)

1.000

 Submucosa (T1b sm1)

4(13.8%)

1.640

0.376–7.150

0.510

 Submucosa (T1b sm2)

6(10.2)

1.160

0.307–4.384

0.826

Ulceration

 Positive

1 (5.9)

0.495

0.061–4.048

0.512

 Negative

13 (11.2)

1.000

Lymphatic invasion

 Positive

7 (41.2)

10.90

3.181–37.35

< 0.001

8.797

1.051–73.64

0.045

 Negative

7 (6.0)

1.000

1.000

Vascular invasion

 Positive

6 (35.3)

7.364

2.159–25.11

0.001

1.126

0.126–10.07

0.915

 Negative

8 (6.9)

1.000

1.000

Perineural invasion

 Positive

0 (0.0)

0.000

0.999

 Negative

14 (10.7)

1.000

Horizontal margin

 Positive

0 (0.0)

0.000

0.999

 Negative

14 (11.5)

1.000

Vertical margin

 Positive

4 (19.0)

2.400

0.675–8.530

0.176

 Negative

10 (8.9)

1.000