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Table 2 Hazard ratios for incidence of hepatocellular carcinoma and mortality according to statin use

From: Statin use and the risk of hepatocellular carcinoma among patients with chronic hepatitis B: an emulated target trial using longitudinal nationwide population cohort data

 

No of case

(100 persons year)

Crude HR

(95% CI)

Adjusted HRa

(95% CI)

HCC

   

Statin nonuser

170 (0.3)

Reference

Reference

Statin user

37 (0.2)

0.56 (0.39, 0.80)

0.56 (0.39, 0.80)

Liver cancer or liver-related mortality

Statin nonuser

86 (0.2)

Reference

Reference

Statin user

17 (0.1)

0.57 (0.33, 0.94)

0.59 (0.35, 0.99)

Extrahepatic cancer-related mortality

Statin nonuser

85 (0.2)

Reference

Reference

Statin user

34 (0.2)

1.13 (0.76, 1.68)

1.12 (0.75, 1.67)

Cardiovascular disease-related mortality

Statin nonuser

42 (0.1)

Reference

Reference

Statin user

14 (0.1)

0.94 (0.51, 1.72)

0.96 (0.52, 1.79)

All-cause mortality

   

Statin nonuser

302 (0.6)

Reference

Reference

Statin user

101 (0.6)

0.94 (0.75, 1.18)

0.93 (0.78, 1.11)

  1. HR Hazard Ratio, CI Confidence Interval, HCC hepatocellular carcinoma
  2. aAdjusted for total cholesterol, LDL cholesterol, use of calcium channel blocker, aspirin, and angiotensin II receptor blocker (covariates with SMD greater than 0.1)