Table 1 Baseline characteristics of study subjects
Statin nonuser (N = 8,525) | Statin user (N = 2,915) | P value | SMD | |
|---|---|---|---|---|
Age, years | 55.85 (9.31) | 56.33 (8.92) | 0.013 | 0.054 |
Sex, male | 4,058 (47.6) | 1,346 (46.2) | 0.19 | -0.029 |
BMI | 0.506 | |||
Underweight (< 18.5 kg/m2) | 107 (1.3) | 30 (1.0) | -0.021 | |
Normal (18.5–23 kg/m2) | 2,185 (25.6) | 723 (24.8) | -0.019 | |
Overweight (23–25 kg/m2) | 2,134 (25.0) | 711 (24.4) | -0.015 | |
Obesity (> 25 kg/m2) | 4,095 (48.0) | 1,449 (49.7) | 0.033 | |
Unknown | 4 (0.0) | 2 (0.1) | 0.009 | |
Drinking | 0.169 | |||
None | 5,108 (59.9) | 1,799 (61.7) | 0.037 | |
Moderate | 3,052 (35.8) | 1,002 (34.4) | -0.030 | |
Heavy | 313 (3.7) | 105 (3.6) | -0.004 | |
Unknown | 52 (0.6) | 9 (0.3) | -0.045 | |
Smoking | 0.564 | |||
None | 5,260 (61.7) | 1,828 (62.7) | 0.021 | |
Past | 1,342 (15.7) | 452 (15.5) | -0.006 | |
Current | 1,906 (22.4) | 632 (21.7) | -0.016 | |
Unknown | 17 (0.2) | 3 (0.1) | -0.025 | |
Physical activity (per week) | 0.016 | |||
None | 6,753 (79.2) | 2,366 (81.2) | 0.049 | |
Regular | 1,730 (20.3) | 543 (18.6) | -0.042 | |
Unknown | 42 (0.5) | 6 (0.2) | -0.049 | |
Total cholesterol, mg/dl | 233.20 (77.15) | 243.09 (34.30) | < 0.001 | 0.166 |
HDL cholesterol, mg/dl | 57.23 (25.60) | 56.71 (27.30) | 0.347 | -0.020 |
LDL cholesterol, mg/dl | 147.30 (80.62) | 154.99 (44.42) | < 0.001 | 0.118 |
AST, U/L | 32.69 (37.57) | 31.85 (26.25) | 0.264 | -0.026 |
ALT, U/L | 35.29 (56.85) | 34.09 (33.27) | 0.281 | -0.026 |
GGT, U/L | 54.23 (106.98) | 50.09 (75.57) | 0.054 | -0.045 |
Systolic blood pressure, mmHg | 126.11 (15.30) | 126.53 (16.41) | 0.205 | 0.027 |
Diastolic blood pressure, mmHg | 78.73 (10.20) | 78.79 (10.50) | 0.792 | 0.006 |
Hypertension (%) | 3,822 (44.8) | 1,442 (49.5) | < 0.001 | 0.093 |
Diabetes (%) | 3,331 (39.1) | 1,232 (42.3) | 0.003 | 0.065 |
Concomitant medication | ||||
Other lipid lowering drug (%) | 10 (0.1) | 12 (0.4) | 0.004 | 0.057 |
Calcium channel blocker (%) | 215 (2.5) | 130 (4.5) | < 0.001 | 0.106 |
ACEI (%) | 29 (0.3) | 21 (0.7) | 0.012 | 0.052 |
Aspirin (%) | 116 (1.4) | 96 (3.3) | < 0.001 | 0.128 |
ARB (%) | 159 (1.9) | 118 (4.0) | < 0.001 | 0.129 |
Beta-blocker (%) | 244 (2.9) | 115 (3.9) | 0.005 | 0.06 |
Warfarin (%) | 4 (0.0) | 1 (0.0) | > 0.999 | -0.006 |
Antiviral medications (%) | 85 (1.0) | 29 (1.0) | > 0.999 | 0 |