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Table 2 Schematic description of adult EoE patients at baseline and after-intervention

From: Extracellular matrix remodeling proteins as biomarkers for clinical assessment and treatment outcomes in eosinophilic esophagitis

 

Baseline

After-intervention

P value

N

29

29

 

Patient characteristics

Age (years), median (IQR)

36.0 (29.5 – 42.5)

 

Gender (male), n (%)

17 (59%)

 

Clinical characteristics

Peak eosinophil count, median (IQR)

50.0 (40.0 – 80.0)

25.0 (4.5 – 40.0)

 < 0.0001a,*

Histological remission, yes, n (%)

 

10 (35)

 

SDI, median (IQR)

5.0 (4.0 – 6.0)

2.0 (0.0 – 4.0)

 < 0.0001a,*

EREFS score (total), median (IQR)

5.0 (4.0 – 5.0)

3.0 (1.0 – 4.0)

 < 0.0001a,*

Fibrotic score, median (IQR)

2.0 (1.0 – 3.0)

1.0 (1.0 – 2.0)

0.0622a

Inflammatory score, median (IQR)

3.0 (2.0 – 3.0)

2.0 (1.0 – 2.0)

 < 0.001a,*

Food impactionI (yes), n (%)

16 (55)

9 (31)

NS

  1. EoE Eosinophilic esophagitis, EREFS Endoscopic features are scored according to the EREFS classification and sub-classified as i) inflammatory signs including white exudates, edema and linear furrows ii) fibrotic signs including rings and strictures, SDI Straumann Dysphagia Instrument; Histological remission, patients with a peak eosinophil count of < 15 eosinophils (eos) per high power field (hpf) after-intervention, IQR Inter quartile range
  2. IPatients with a score of ≥ 3 on item-2 (dysphagia intensity) of the SDI-measure were defined as having symptoms of ‘food impaction’
  3. aP value baseline vs. after-intervention (Wilcoxon signed rank test)
  4. *P-value (two-sided) of < 0.05, indicating a significant outcome