Skip to main content
Fig. 3 | BMC Gastroenterology

Fig. 3

From: PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer: a retrospective study

Fig. 3

SNVs of PINK1 gene detected in this study. a The full-length PINK1 can be divided into five structural and functional regions: MTS, OMS, TMD, KD, and CTD. p indicates the p-value. CTD: C-terminal domain, KD: kinase domain, MTS: mitochondrial targeting sequence, OMS: outer membrane localization signal, TMD: transmembrane domain. b Samples with AltSeq for PINK1 are shown in red. Samples whose sequence reads did not satisfy the criteria are marked in yellow. c, d Sequencing chromatograms illustrating PINK1 c.1018G > A and c.1562A > C. * indicates the location of the SNV. c Integrative Genomics Viewer screenshot of soft-clipped reads in exons 5 and 8 of PINK1. Green represents A, yellow represents G, and blue represents C. d Sanger sequencing data

Back to article page

BMC Gastroenterology

ISSN: 1471-230X

Contact us