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Fig. 2 | BMC Gastroenterology

Fig. 2

From: Biochemical and histopathological evidence for beneficial effects of Empagliflozin pretreatment on acetic acid-induced colitis in rats

Fig. 2

Effects of EMPA and Dexa on colonic macroscopic damage in rats with AA-induced colitis. pretreatment with EMPA or Dexa was done for 4 consecutive days before induction of colitis by AA. Control and AA groups received vehicle in an equal volume. (A) Macroscopic appearance of colonic mucosa of normal rats, showing normal mucosa with intact epithelial surface. (B) Macroscopic appearance of colonic mucosa of AA group showing severe ulceration (blue arrows), and tissue necrosis (red arrows) of the colon tissue. (C) Macroscopic appearance of colonic mucosa of AA + EMPA group. (D) Macroscopic appearance of colonic mucosa of AA + Dexa group (E). Mean scores of the tissue damage observed in colonic specimens of animals in different experimental groups. The results were expressed as mean ± SEM (n = 6). #p < 0.05 vs. AA group; ###p < 0.001 vs. AA, &p < 0.05 vs. AA + EMPA group. AA: Acetic acid, EMPA: Empagliflozine, Dexa: Dexamethasone

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BMC Gastroenterology

ISSN: 1471-230X

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