Table 3 Demographic, clinical and laboratory features of HCC patients with positive HBsAg as compared to HCC patients with negative HBsAg

Age(yrs)Mean

39.9

51.4

< 0.0001

Age groups

 < 35

59(34.7)

13(15.1)

< 0.0001

 35–44

65(38.2)

18(20.9)

 45–54

28(16.5)

19(22.1)

 55–64

12(7.1)

11(12.8)

 ≥ 65

6(3.5)

25(29.1)

Sex (M:F)

145(85.3):25(14.7)

62(72.1):24(27.9)

0.011

Clinical features

 1. Constitutional symptoms

  Fever

143(84.1)

69(79.1)

0.480

  Night sweat

116(68.2)

54(62.8)

0.414

  Weight loss

154(90.5)

79(91.9)

0.723

  Easy fatiguability

153(90)

80(93)

0.328

 2. GI symptoms

  Abdominal pain

156(91.8)

68(79.1)

0.002

  Early satiety

150(88.2)

75(87.2)

0.801

  Abdominal distension

139(81.8)

66(76.7)

0.329

  Anorexia

137(80.6)

63(73.3)

0.170

  Nausea

108(63.5)

51(59.3)

0.468

  Vomiting

65(38.2)

32(37.2)

0.955

  Bloody stool

49(28.8)

24(27.9)

0.922

  Diarrhoea

64(37.6)

24(27.9)

0.112

  Yellow eyes

78(45.9)

29(33.7)

0.042

  Dark urine

117(68.8)

46(53.5)

0.018

  Pruritus

50(29.4)

27(31.4)

0.677

  Oedema

58(34.1)

34(39.5)

0.392

Medical history

 Hypertension

8(4.7)

10(11.6)

0.039

 Anaemia

44(25.9)

20(23.3)

0.664

 Cigarette smoking

68 (40)

27 (31.4)

0.215

 Alcohol

11(6.4)

5(5.8)

0.865

Examination

 Oedema

53 (31.2)

35( 40.7)

0.100

 Jaundice

54 (31.8)

21(24.4)

0.239

 Hepatomegaly

132 (77.6)

70 (81.4)

0.236

 Splenomegaly

19 (11.2)

9 (10.5)

0.887

 Ascites

58 (34.1)

29(33.7)

0.973

 Collateral veins

30 (17.6)

13 (15.1)

0.620

 Abdominal tenderness

82 (48.2)

22(25.6)

0.001

Laboratory investigations

 Alpha-fetoprotein (ng/ml)

4780.48 (3- 116000)

2527.46(1.07–94600)

0.385

 Haemoglobin (g/dl)

11.4( 4.8–18.4)

11.2 ( 5.6–16.8)

0.248

 White Cell Count (× 10⁹/l)

8.25( 1.8–34.8)

7.6 (2.2- 27.8)

0.238

 Red cell count (× 10¹²/l)

4.21(0.9- 7.67)

4.01(2.34–6.9)

0.314

 Platelet count (× 10⁹/l)

207(33–941)

252(52- 641)

0.021

 Sodium (mmol/l)

138(122–151)

139(121–147)

0.228

 Potassium (mmol/l)

4.4(2.36–10.6)

4.1(3.1–6.1)

0.074

 Creatinine( umol/l)

65( 13–949)

68.5(37–744)

0.247

 Glucose (mmol/l)

4.45( 0.9–13.4)

4.65(2.7–8.4)

0.105

 Aspartate Transferase (U/L)

224.5(32–7886)

153(18–610)

< 0.001

 Alanine Transferase (U/L)

71(5–937)

47(8–271)

< 0.001

 Total Bilirubin (umol/l)

37.5(0–646)

25(6–273)

0.0625

 Gamma glutamyl Transferase (U/L)

305(14–1826)

344(11–3677)

0.851

 Alkaline phosphatase (U/L)

281(28–4063)

282(70–1902)

0.820

 Albumin (g/L)

33(15–52)

33(20–45)

0.551

Survival

 Median survival (Days)

31(1–448)

41(3–510)

0.175