Efficacy of washed microbiota transplantation for therapeutic targets of refractory functional constipation and the influencing factors: a single-center, retrospective, 24-week follow-up study

Table 4 Influence of the courses of washed microbiota transplantation on major primary and secondary outcomes in functional constipation patients at weeks 8 and 24, as determined by multivariate logistic regression analysis

Variable	At week 8		At week 24
Variable	Odds ratio (95% CI)	P-value	Odds ratio (95% CI)	P-value
Primary outcomes
Straining improvement rate	4.458 (1.412–14.075)	0.011	2.177 (0.693–6.836)	0.183
Hard stools improvement rate	3.354 (1.101–10.222)	0.033	2.182 (0.727–6.548)	0.164
Decreased stool frequency improvement rate Overall response	35.889 (4.109-313.423) 6.944 (2.215–21.776)	0.001 0.001	4.897 (1.322–18.139) 3.782 (1.312–10.903)	0.017 0.014
Secondary outcomes
Clinical remission rate	4.571 (1.222–17.097)	0.024	2.109 (0.558–7.975)	0.272
Clinical improvement rate	10.214 (1.398–74.623)	0.022	5.668 (1.436–22.363)	0.013

WMT, washed microbiota transplantation; CI, confidence interval. Decreased stool frequency, fewer than three spontaneous complete bowel movements per week;
Comparison between two or more courses versus one course of WMT.

ISSN: 1471-230X