Baseline characteristics | Improvement of therapeutic targets and overall response& | ||||||
---|---|---|---|---|---|---|---|
Straining (21 vs. 39) | Hard stools (22 vs. 35) | Incomplete evacuation (5 vs. 9) | Anorectal obstruction (4 vs. 5) | Decreased stool frequency (23 vs. 23) | Overall response (27 vs. 36) | ||
Sex | Â | Â | Â | Â | Â | Â | Â |
Male (n = 29) | 46.0% | 57.1% vs. 56.4% | 50.0% vs. 57.1% | 60.0% vs. 55.6% | 75.0% vs. 80.0% | 52.2% vs. 43.5% | 55.6% vs. 52.8% |
Female (n = 44) | 54.0% | 42.9% vs. 43.6% | 50.0% vs. 42.9% | 40.0%vs. 44.4% | 25.0% vs. 20.0% | 47..8% vs. 56.5% | 44.4% vs. 47.2% |
Age, year | 60.8 ± 15.0 | 62.0 ± 10.7 vs. 60.0 ± 17.1 | 61.0 ± 11.6 vs. 60.3 ± 17.0 | 62.8 ± 12.0 vs. 63.8 ± 6.2 | 59.3 ± 4.6 vs. 72.0 ± 3.1 | 60.7 ± 11.0 vs.61.0 ± 18.3 | 61.4 ± 10.9 vs. 60.4 ± 17.5 |
Duration of disease, year | 6 (2–12) | 10 (4-12.5) vs. 6 (1–15) | 10 (4.5–20) vs. 5 (1–10) | 3 (0.5–10) vs. 5 (1–15) | 11.5 (2.25–27.5) vs. 2 (1-12.5) | 10 (5–20) vs. 5 (1–10)** | 10 (3–15) vs. 5 (1-11.5) |
Number of SCBMs/week | 2 (1–3) | 5 (4–6) vs. 2 (2–3)* | 5 (3-5.25) vs. 2 (2–3)* | 5 (3-6.5) vs. 4 (2–7) | 4.5 (2.5–6.5) vs.3 (2-6.5) | 4 (3–5) vs. 2 (2–2)* | 5 (3–6) vs. 2 (2–3)* |
BSFS score | 2 (1–2) | 3 (3–4) vs. 2 (2–3)* | 3 (3–4) vs. 2 (2–2)* | 3 (2.5-4) vs. 2 (1.5–4.5) | 3.5 (2.25–4.75) vs. 2 (1.5–3.5) | 3 (3–4) vs. 2 (2–2)* | 3 (3–4) vs. 2 (2–2)* |
Wexner constipation score | 9 (8–11) | 6 (3–7) vs. 9 (8–10)* | 6 (3-7.25) vs. 9 (8–10)* | 6 (3-9.5) vs. 9 (6–10) | 9 (2.5-11.75) vs. 8 (4.5–9.5) | 7 (5–9) vs. 9 (8–10)* | 6 (3–8) vs. 9 (8–10)* |
Course of WMT | 1 (1–3) | 2 (1-2.5) vs. 1 (1–3) | 1.5 (1–3) vs. 1 (1–2) | 3 (1-3.5) vs. 1 (1-2.5) | 1 (1-2.5) vs. 1 (1-2.5) | 2 (1–3) vs. 1 (1–2)* | 2 (1–3) vs. 1 (1–2)* |
1 (n = 37)# | 58.7% | 47.6% vs. 64.1% | 50.0% vs. 68.6% | 40.0% vs. 55.6% | 75.0% vs. 60.0% | 39.1% vs. 73.9% | 40.7% vs. 72.2% |
2 (n = 10) | 15.9% | 28.6% vs. 7.7%* | 22.7% vs. 11.4% | 0.0% vs. 22.2% | 0.0% vs. 20.0% | 17.4% vs. 13.0% | 25.9% vs. 8.3%* |
3 (n = 9) | 14.3% | 4.8% vs. 20.5% | 9.1% vs. 14.3% | 40.0% vs. 11.1% | 25.0% vs. 20.0% | 26.1% vs. 13.0% | 14.8% vs. 13.9% |
4 (n = 7) | 11.1% | 19.0% vs. 7.7% | 18.2% vs. 5.7% | 20.0% vs. 11.1% | 0.0% vs. 0.0% | 17.4% vs. 0.0% | 18.5% vs. 5.6%** |
Course of WMT ≥2 (n = 26) | 41.3% | 52.4% vs. 35.9% | 50.0% vs. 31.4% | 60.0% vs. 44.4% | 25.0% vs. 40.0% | 60.9% vs. 26.1%* | 59.3% vs. 27.8%* |
History of laxative use | 76.2% | 57.1% vs. 84.6%* | 72.7% vs. 80.0% | 60.0% vs. 88.9% | 75.0% vs. 60.0% | 78.3% vs. 78.3% | 70.4% vs. 80.6% |