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Table 3 Results of tumor characteristics

From: Comparison of clinicopathologic characteristics among patients with HBV-positive, HCV-positive and Non-B Non-C hepatocellular carcinoma after hepatectomy: a systematic review and meta-analysis

Variables

No. of studies

No. of patients

RR/MDa

95% CI

Test for overall effect

Heterogeneity

     

P

P

I2 (%)

Tumor size (cm)

 NBNC-HCC versus B-HCC

15 [9, 11, 14, 23, 25, 29, 32, 33, 35, 36, 38,39,40, 43, 45]

2485

0.52

-0.08, 1.11

0.09

 < 0.00001

95

 NBNC-HCC versus C-HCC

13 [9, 11, 14, 23, 25, 29, 32, 33, 35, 36, 39, 40, 43]

3759

1.29

0.93, 1.66

 < 0.00001

 < 0.00001

83

 NBNC-HCC versus BC-HCC

4 [9, 11, 23, 29]

220

-0.12

-0.70, 0.46

0.69

0.006

76

Multiple tumors

 NBNC-HCC versus B-HCC

24 [9, 10, 13,14,15, 21, 23, 25,26,27,28,29,30, 32,33,34, 36,37,38, 40, 42,43,44,45]

13,814

0.82

0.71, 0.94

0.005

0.04

36

 NBNC-HCC versus C-HCC

19 [9, 10, 14, 15, 21, 23, 25,26,27,28,29,30, 32, 33, 36, 37, 40, 43, 44]

13,494

0.79

0.67, 0.93

0.004

0.04

39

 NBNC-HCC versus BC-HCC

5 [9, 23, 27, 29, 30]

418

0.59

0.29, 1.21

0.15

0.07

53

Well-formed capsule

 NBNC-HCC versus B-HCC

14 [10, 11, 13, 14, 23, 24, 29, 34, 36,37,38, 40, 41]

6745

1.00

0.89, 1.11

0.95

 < 0.00001

76

 NBNC-HCC versus C-HCC

10 [10, 11, 14, 23, 24, 28, 29, 36, 37, 40]

2109

0.92

0.85, 0.99

0.03

0.28

18

 NBNC-HCC versus BC-HCC

4 [11, 23, 24, 29]

249

1.11

0.84, 1.47

0.46

0.63

0

Edmondson-Steiner grade (I + II)

 NBNC-HCC versus B-HCC

6 [11, 13, 22, 23, 34, 38]

5104

1.01

0.93, 1.09

0.85

0.19

33

 NBNC-HCC versus C-HCC

3 [11, 22, 23]

308

1.19

0.81, 1.76

0.38

0.12

53

Vascular invasion

 NBNC-HCC versus B-HCC

15 [9, 11, 13, 14, 23, 24, 29, 30, 33, 38, 39, 42, 44,45,46]

7851

0.79

0.66, 0.94

0.008

0.001

61

 NBNC-HCC versus C-HCC

10 [9, 11, 14, 23, 24, 29, 30, 33, 39, 44]

2433

0.95

0.78, 1.16

0.64

0.08

42

 NBNC-HCC versus BC-HCC

5 [11, 23, 24, 29, 30]

292

0.60

0.40, 0.89

0.01

0.45

0

Liver cirrhosis

 NBNC-HCC versus B-HCC

24 [9, 10, 13,14,15, 21,22,23,24, 27,28,29,30, 32, 33, 35,36,37, 39, 40, 42, 44,45,46]

13,837

0.66

0.58, 0.76

 < 0.00001

 < 0.00001

85

 NBNC-HCC versus C-HCC

20 [9, 10, 14, 15, 21,22,23,24, 27,28,29,30, 32, 33, 35,36,37, 39, 40, 44]

14,231

0.64

0.56, 0.73

 < 0.00001

 < 0.00001

71

 NBNC-HCC versus BC-HCC

6 [9, 23, 24, 27, 29, 30]

471

0.65

0.53, 0.81

 < 0.00001

0.17

36

  1. RR Risk Ratio, MD, mean difference, CI Confidence Interval, NBNC-HCC both HBV and HCV- negative HCC, B-HCC HBV-positive and HCV-negative HCC, C-HCC HBV-negative and HCV-positive HCC, BC-HCC both HBC and HCV-positive HCC
  2. aRR was used to assess dichotomous variables (Multiple tumors, Well-formed capsule, Edmondson-Steiner grade (I + II), Vascular invasion and Liver cirrhosis), and MD was used to assess continuous variables (Tumor size). The NBNC-HCC group was the reference group
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BMC Gastroenterology

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