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Table 2 Results of laboratory findings and operative methods

From: Comparison of clinicopathologic characteristics among patients with HBV-positive, HCV-positive and Non-B Non-C hepatocellular carcinoma after hepatectomy: a systematic review and meta-analysis

Variables

No. of studies

No. of patients

RR/MDa

95% CI

Test for overall effect

Heterogeneity

     

P

P

I2 (%)

ALT (U/L)

 NBNC-HCC versus B-HCC

14 [9, 11, 14, 22, 24, 25, 29, 32, 33, 38, 39, 43, 45]

2126

-9.62

-14.08, -5.17

 < 0.0001

 < 0.0001

68

 NBNC-HCC versus C-HCC

12 [9, 11, 14, 22, 24, 25, 29, 32, 33, 39, 40, 43]

3100

-25.04

-34.95, -15.13

 < 0.00001

 < 0.00001

93

 NBNC-HCC versus BC-HCC

4 [9, 11, 24, 29]

213

-29.34

-43.25, -15.43

 < 0.0001

0.39

1

AST (U/L)

 NBNC-HCC versus B-HCC

13 [9, 11, 14, 22, 24, 25, 28, 32, 35, 38,39,40, 43]

1672

-6.57

-12.59, -0.55

0.03

 < 0.0001

71

 NBNC-HCC versus C-HCC

11 [9, 11, 14, 22, 24, 25, 32, 35, 39, 40, 43]

3003

-18.39

-24.47, -12.32

 < 0.00001

 < 0.00001

82

 NBNC-HCC versus BC-HCC

3 [9, 11, 24]

126

-34.91

-74.48, 4.67

0.08

0.0005

87

T-Bil (mg/dL)

 NBNC-HCC versus B-HCC

15 [11, 14, 15, 21, 24, 28, 29, 32, 33, 35, 36, 38,39,40, 43]

7088

-0.09

-0.16, -0.01

0.02

 < 0.00001

84

 NBNC-HCC versus C-HCC

12 [11, 14, 21, 24, 29, 32, 33, 35, 36, 39, 40, 43]

3472

-0.07

-0.16, -0.01

0.09

 < 0.00001

84

 NBNC-HCC versus BC-HCC

3 [11, 24, 29]

189

-0.48

-1.27, 0.32

0.24

 < 0.00001

93

Albumin (g/dL)

 NBNC-HCC versus B-HCC

17 [9, 11, 14, 15, 21, 25, 28, 29, 33, 35,36,37,38,39,40, 42, 43]

8439

0.05

-0.00, 0.09

0.05

 < 0.00001

89

 NBNC-HCC versus C-HCC

14 [9, 11, 14, 21, 25, 28, 29, 33, 35,36,37, 39, 40, 43, 44]

3903

0.23

0.15, 0.31

 < 0.00001

 < 0.00001

81

 NBNC-HCC versus BC-HCC

3 [9, 11, 29]

160

0.23

-0.11, 0.56

0.18

0.02

75

Platelet (× 104/μL)

 NBNC-HCC versus B-HCC

12 [11, 14, 25, 29, 32, 33, 35, 36, 38,39,40, 43]

1961

3.21

2.40, 4.02

 < 0.00001

0.37

8

 NBNC-HCC versus C-HCC

11 [11, 14, 25, 29, 32, 33, 35, 36, 39, 40, 43]

3478

4.66

3.72, 5.60

 < 0.00001

0.04

48

ICG-R15 (%)

 NBNC-HCC versus B-HCC

14 [9, 21,22,23,24,25, 32, 33, 35, 36, 39, 40, 42, 43]

3117

0.34

-0.34, 1.02

0.33

 < 0.00001

75

 NBNC-HCC versus C-HCC

13 [9, 21,22,23,24,25, 32, 33, 35, 36, 39, 40, 43]

3324

-4.85

-6.04, -3.65

 < 0.00001

0.0003

67

 NBNC-HCC versus BC-HCC

3 [9, 23, 24]

137

-0.27

-5.82, 5.29

0.93

0.09

59

AFP (ng/mL)

 NBNC-HCC versus B-HCC

13 [9, 11, 14, 21, 25, 30, 32, 33, 35, 39, 40, 43, 46]

1741

-2172.21

-4081.13, -263.30

0.03

 < 0.00001

83

 NBNC-HCC versus C-HCC

12 [9, 11, 14, 21, 25, 30, 32, 33, 35, 39, 40, 43]

3581

519.17

-1.00, 1039.35

0.05

0.33

12

 NBNC-HCC versus BC-HCC

3 [9, 11, 30]

116

558.99

-464.56, 1582.54

0.28

0.20

38

DCP (mAU/mL)

 NBNC-HCC versus B-HCC

6 [14, 30, 33, 35, 40, 43]

1002

247.02

-1210.87, 1704.91

0.74

0.20

31

 NBNC-HCC versus C-HCC

6 [14, 30, 33, 35, 40, 43]

2102

1772.52

57.20, 3487.85

0.04

0.03

60

Anatomic resection

 NBNC-HCC versus B-HCC

12 [11, 14, 29, 30, 32,33,34,35,36, 40, 41, 44]

2619

1.14

1.01, 1.29

0.03

 < 0.0001

72

 NBNC-HCC versus C-HCC

10 [11, 14, 29, 30, 32, 33, 35, 36, 40, 44]

2937

1.24

1.08, 1.43

0.003

 < 0.0001

79

 NBNC-HCC versus BC-HCC

3 [11, 29, 30]

179

0.97

0.82, 1.16

0.76

0.63

0

  1. RR Risk Ratio, MD Mean difference, CI Confidence Interval, NBNC-HCC Both HBV and HCV- negative HCC, B-HCC HBV-positive and HCV-negative HCC, C-HCC HBV-negative and HCV-positive HCC, BC-HCC Both HBC and HCV-positive HCC, ALT Alanine aminotransferase, AST Aspartate aminotransferase, T-Bil Total bilirubin, ICG-R15 Indocyanine green retention rate at 15 min AFP, alfa-fetoprotein, DCP Des-gamma-carboxy prothrombin
  2. aRR was used to assess dichotomous variables (Anatomic resection), and MD was used to assess continuous variables (ALT, AST, T-Bil, Albumin, Platelet, ICG-R15, AFP and DCP). The NBNC-HCC group was the reference group
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BMC Gastroenterology

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