From: Second primary colorectal cancer in adults: a SEER analysis of incidence and outcomes
Variables | OR (95%CI) | P | OR (95%CI) | P |
---|---|---|---|---|
Age | 1.01 (1.01–1.01) |  < 0.001 | 1.01 (1.01–1.01) |  < 0.001 |
Sex | ||||
 Female | Ref |  | Ref |  |
 Male | 1.09 (1.03–1.15) | 0.004 | 1.17 (1.10–1.24) |  < 0.001 |
Race | ||||
 Black | Ref |  |  |  |
 Unknown | 0.91 (0.80–1.03) | 0.126 | 0.91 (0.80–1.03) | 0.133 |
 White | 1.02 (0.93–1.11) | 0.743 | 0.95 (0.87–1.04) | 0.257 |
Insurance | ||||
 Any Medicaid | Ref |  | Ref |  |
 Insured | 0.96 (0.86–1.07) | 0.463 | 0.87 (0.78–0.97) | 0.010 |
 Insured/No specifics | 1.12 (0.99–1.28) | 0.083 | 0.98 (0.86–1.12) | 0.797 |
 Uninsured | 1.10 (0.89–1.36) | 0.387 | 1.09 (0.88–1.35) | 0.453 |
 Blank(s) | 1.53 (1.37–1.70) |  < 0.001 | 1.37 (1.29–1.53) |  < 0.001 |
Tumor site | ||||
 Left colon | Ref |  | Ref |  |
 Other cancer | 0.22 (0.03–1.54) | 0.127 | 0.79 (0.11–5.66) | 0.814 |
 Other digestive | 0.30 (0.27–0.32) |  < 0.001 | 0.46 (0.42–0.50) |  < 0.001 |
 Other rectum | 0.53 (0.49–0.59) |  < 0.001 | 0.74 0.66–0.82) |  < 0.001 |
 Right colon | 0.78 (0.73–0.84) |  < 0.001 | 0.73 (0.68–0.79) |  < 0.001 |
Histology | ||||
 Adenocarcinoma | Ref |  |  |  |
 Mucous adenocarcinoma | 1.27 (1.14–1.42) |  < 0.001 | 1.19 (1.07–1.33) | 0.002 |
 Signet ring cell carcinoma | 0.55 (0.42–0.71) |  < 0.001 | 0.91 (0.70–1.20) | 0.481 |
 Others | 0.49 (0.45–0.52) |  < 0.001 | 0.85 (0.78–0.93) |  < 0.001 |
Grade | ||||
 Grade I/Grade II | Ref |  |  |  |
 Grade III/Grade IV | 0.76 (0.70–0.82) |  < 0.001 | 0.92 (0.84–0.99) | 0.039 |
 Unknown | 0.41 (0.38–0.45) |  < 0.001 | 0.73 (0.66–0.80) |  < 0.001 |
T stage | ||||
 T2 | Ref |  |  |  |
 T3 | 1.32 (1.23–1.41) |  < 0.001 | 1.61 (1.40–1.85) |  < 0.001 |
 T4 | 1.24 (1.12–1.36) |  < 0.001 | 1.90 (1.63–2.22) |  < 0.001 |
 Unknown | 0.53 (0.49–0.59) |  < 0.001 | 1.28 (1.01–1.61) | 0.040 |
N stage | ||||
 N0 | Ref |  |  |  |
 N1 | 0.75 (0.70–0.81) |  < 0.001 | 0.87 (0.76–0.99) | 0.044 |
 N2 | 1.08 (0.98–1.19) | 0.108 | 1.09 (0.93–1.27) | 0.312 |
 N3 | 0.30 (0.14–0.64) | 0.002 | 0.71 (0.32–1.57) | 0.394 |
 Unknown | 0.34 (0.31–0.38) |  < 0.001 | 0.78 (0.62–0.98) | 0.036 |
M stage | ||||
 M0 | Ref |  |  |  |
 M1 | 0.40 (0.36–0.44) |  < 0.001 | 0.49 (0.30–0.80) | 0.004 |
 Unknown | 0.34 (0.30–0.38) |  < 0.001 | 0.53 (0.41–0.68) |  < 0.001 |
AJCC stage | ||||
 I | Ref |  |  |  |
 II | 1.12 (1.03–1.21) | 0.005 | 0.70 (0.60–0.82) |  < 0.001 |
 III | 1.05 (0.96–1.13) | 0.279 | 0.69 (0.56–0.84) | 0.001 |
 IV | 0.42 (0.38–0.48) |  < 0.001 | 0.66 (0.41–0.08) | 0.090 |
 Unknown | 0.46 (0.41–0.51) |  < 0.001 | 0.83 (0.64–1.06) | 0.138 |
Radiation | ||||
 No/Unknown | Ref |  |  |  |
 Yes | 0.68 (0.62–0.74) |  < 0.001 | 0.69 (0.57–0.83) |  < 0.001 |
Chemotherapy | ||||
 No/Unknown | Ref |  |  |  |
 Yes | 0.70 (0.66–0.74) |  < 0.001 | 0.93 (0.86–1.00) | 0.055 |
Radiation sequence | ||||
 Only one | Ref |  | Ref |  |
 After | 0.93 (0.82–1.05) | 0.252 | 1.52 (1.22–1.88) | 0.001 |
 Before | 0.72 (0.63–0.84) |  < 0.001 | 0.95 (0.76–1.20) | 0.687 |
 Both | 0.46 (0.21–1.03) | 0.059 | 0.64 (0.28–1.46) | 0.288 |
 Unknown | 1.04 (0.39–2.78) | 0.940 | 1.59 (0.59–4.28) | 0.358 |