Table 4 The conserved motifs found in promoters of DEGs by MEME analysis. The UFRs of DEGs were analyzed to identify the conserved motifs and CREs. The extracted UFR sequences were analyzed using TOMTOM to find significant motifs, and selected motifs were analyzed using GOMO. Ten significant motifs were detected with lengths ranging from 20 to 24nt in length
# | Motif | Transcription Factors | Logo | Top 5 Specific Predictions |
|---|---|---|---|---|
1 | KLF16_HUMAN.H11MO.0.D | KLF16 |
| CC transcription factor complex BP negative regulation of signal transduction MF chromatin binding MF protein homodimerization activity MF protein heterodimerization activity |
2 | MAZ_HUMAN.H11MO.0.A | MAZ |
| CC transcription factor complex BP negative regulation of signal transduction MF protein heterodimerization activity MF protein homodimerization activity CC dendrite |
3 | PATZ1_HUMAN.H11MO.0.C | PATZ1 |
| CC transcription factor complex BP negative regulation of signal transduction MF protein heterodimerization activity MF protein homodimerization activity BP inner ear morphogenesis |
4 | SP1_HUMAN.H11MO.0.A | SP1 |
| CC transcription factor complex BP negative regulation of signal transduction MF potassium ion binding BP negative regulation of neuron apoptosis BP potassium ion transport |
5 | SP2_HUMAN.H11MO.0.A | SP2 |
| CC transcription factor complex BP negative regulation of signal transduction MF protein heterodimerization activity BP neuron fate commitment MF chromatin binding |
6 | SP3_HUMAN.H11MO.0.B | SP3 |
| CC transcription factor complex BP negative regulation of signal transduction MF protein heterodimerization activity MF protein homodimerization activity MF chromatin binding |
7 | TBX15_HUMAN.H11MO.0.D | TBX15 |
| CC transcription factor complex BP negative regulation of signal transduction MF protein heterodimerization activity MF protein homodimerization activity MF chromatin binding |
8 | VEZF1_HUMAN.H11MO.0.C | VEZF1 |
| CC transcription factor complex CC dendrite MF transcription activator activity MF protein heterodimerization activity BP negative regulation of signal transduction |
9 | WT1_HUMAN.H11MO.0.C | WT1 |
| CC transcription factor complex MF protein heterodimerization activity BP negative regulation of signal transduction CC dendrite MF potassium ion binding |
10 | ZN467_HUMAN.H11MO.0.C | ZNF467 |
| CC transcription factor complex BP negative regulation of signal transduction MF protein heterodimerization activity MF protein homodimerization activity BP inner ear morphogenesis |
