Table 2 List of hub genes identified by using CytoHubba. CytoHubba software (version 0.1) was used to draw the PPI network and identify hub proteins between all nodes. The hub analysis resulted in the identification of 11 genes with the most interactions
# | Node | Gene ID | Ensembl | Gene Description | Rank | Ranking Method | Other names | Location |
|---|---|---|---|---|---|---|---|---|
1 | ATP5A1 | 498 | ENSG00000152234 | ATP synthase F1 subunit alpha | 1 | MCC, MNC, Degree | OMR; ORM; ATPM; MOM2; ATP5A; hATP1; ATP5F1A; MC5DN4; ATP5AL2; COXPD22; HEL-S-123Â m | 18q21.1 |
2 | ATP5B | 506 | ENSG00000110955 | ATP synthase F1 subunit beta | 2 | MCC, MNC, Degree | ATP5F1B; ATPMB; ATPSB; HEL-S-271 | 12q13.3 |
3 | NDUFS3 | 4722 | ENSG00000213619 | NADH: ubiquinone oxidoreductase core subunit S3 | 3 | MCC | CI-30; MC1DN8 | 11p11.2 |
4 | COX6C | 1345 | ENSG00000164919 | Cytochrome c oxidase subunit 6C | 4 | MCC | - | 8q22.2 |
5 | MT-ND6 | 4541 | ENSG00000198695 | mitochondrially encoded NADH dehydrogenase 6 | 1 | DMNC | MTND6; ND6 | MT (non-nuclear) |
6 | MT-ATP8 | 4509 | ENSG00000228253 | mitochondrially encoded ATP synthase 8 | 2 | DMNC | ATPase8; MTATP8; ATP8 | MT (non-nuclear) |
7 | MT-ND4 | 4538 | ENSG00000198886 | mitochondrially encoded NADH dehydrogenase 4 | 3 | DMNC | MTND4; ND4 | MT (non-nuclear) |
8 | COX7A2 | 1347 | ENSG00000112695 | cytochrome c oxidase subunit 7A2 | 4 | DMNC | VIIAL; COX7AL; COX7AL1; COXVIIAL; COXVIIa-L | 6q14.1 |
9 | RPL8 | 6132 | ENSG00000161016 | ribosomal protein L8 | 2 | MNC, Degree | L8 | 8q24.3 |
10 | ATP5D | 513 | ENSG00000099624 | ATP synthase F1 subunit delta | 2 | MNC | ATP5F1D; MC5DN5 | 19p13.3 |
11 | RPS16 | 6217 | ENSG00000105193 | ribosomal protein S16 | 2 | Degree | S16 | 19q13.2 |