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Table 4 Variables associated with symptom cluster membership: results from univariate and multinomial regression analyses

From: Symptoms and symptom clusters in patients newly diagnosed with inflammatory bowel disease: results from the IBSEN III Study

 

Psychological cluster vs. physical cluster

Impaired energy cluster vs. physical cluster

 

Univariate

Multinomial

Univariate

Multinomial

Variable

OR

95% CI

p-value

OR

95% CI

p-value

OR

95% CI

p-value

OR

95% CI

p-value

Gender

 Male (ref)

1

     

1

     

 Female

0.75

0.41–1.38

0.35

0.91

0.46–1.81

0.79

1.07

0.55–2.09

0.85

1.22

0.57–2.61

0.62

 Age

1.0

0.98–1.02

0.89

0.99

0.97–1.02

0.63

1.00

0.98–1.02

0.98

0.99

0.96–1.02

0.38

Diagnosis

 UC (ref)

1

     

1

     

 CD

0.81

0.42–1.55

0.52

-

  

1.14

0.55–2.36

0.72

-

  

Marital status

 Married/co-habitant (ref)

1

     

1

     

 Single/widowed

1.22

0.64–2.31

0.54

-

  

1.00

0.50–2.02

0.99

-

  

Education level

 >12 years (ref)

1

     

1

     

 <12 years

0.93

0.51–1.70

0.81

-

  

1.61

0.82–3.17

0.17

1.57

0.74–3.35

0.24

Work status

 Working (ref)

1

     

1

     

 Not working

0.65

0.25–1.64

0.36

-

  

0.78

0.28–2.18

0.64

-

  

Calprotectin

 < 250 µg/g (ref)

1

     

1

     

 ≥ 250 µg/g

1.76

0.89–3.48

0.10

1.80

0.88–3.69

0.11

2.07

0.98–4.36

0.06

1.69

0.76–3.75

0.20

HBI/SCCAI*

 Remission (ref)

1

     

1

     

 Disease activity

1.38

0.73–2.59

0.32

-

  

1.84

0.92–3.68

0.08

1.46

0.66–3.21

0.35

25(OH) vitamin D**

 Normal(ref)

1

     

1

     

 Deficiency

1.11

0.58–2.13

0.74

-

 

-

2.06

0.96–4.42

0.07

2.49

1.00-6.20

0.05

Ferritin***

 Normal (ref)

1

     

1

     

 Iron deficiency

0.85

0.42–1.71

0.65

-

  

0.87

0.43–1.87

0.72

-

  

Hemoglobin***

 Normal (ref)

1

     

1

     

 Anemia

1.09

0.46–2.57

0.85

-

  

1.47

0.54-4.00

0.45

-

  
  1. Physical cluster was used as reference group
  2. Significant p-value marked in bold
  3. Abbreviations: CD Crohn’s disease, UC Ulcerative colitis, HBI Harvey Bradshaw Index, SCCAI Simple Clinical Colitis Index, OR Odds ratio, CI Confidence interval
  4. *Clinical disease activity score: HBI ≥ 5 for CD and SCCAI ≥ 2.5 for UC
  5. ** Normal vitamin D: ≥50 nmol/L. Vitamin D deficiency: <50 nmol/L
  6. ** If calprotectin < 250 µg/g and ferritin < 30 µg/L: indicative of iron deficiency. If calprotectin ≥ 250 µg/g and ferritin < 100 µg/L: indicative of iron deficiency
  7. *** Normal values: ≥12 g/dl for females and ≥ 13 g/dl for male patients. Anemia: hemoglobin levels of < 12 g/dl for females and < 13 g/dl for men
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BMC Gastroenterology

ISSN: 1471-230X

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