Table 3 Prognostic factors for recurrence-free survival in patients with non-B non-C hepatocellular carcinoma

Age > 70 years

1.13

0.80–1.59

0.491

-

Gender (male)

1.27

0.80–2.00

0.311

-

BMI > 22 kg/m²

0.99

0.68–1.44

0.955

-

HT (yes)

1.23

0.76–2.00

1.23

-

DM (yes)

1.20

0.86–1.69

0.289

-

Dyslipidemia (yes)

1.00

0.31–3.20

0.995

-

Heavy drinking (yes)

0.97

0.69–1.37

0.869

-

Smoking (yes)

1.00

0.72–1.42

0.986

-

Serum ALT > 40 IU/L

1.79

1.27–2.53

 < 0.001

1.45

0.99–2.11

0.053

Fib 4 score > 2.67

1.28

1.91–1.80

0.150

-

Platelet count < 8.0 × 10⁴/ml

0.94

0.49–1.80

0.853

-

ICGR15 > 10%

1.50

1.03–2.19

0.037

1.30

0.87–1.97

0.204

AFP > 100 ng/ml

2.14

1.52–3.02

 < 0.001

1.75

1.19–2.56

0.004

DCP > 40 mIU/ml

1.69

1.16–2.46

0.007

1.35

0.89–2.06

0.158

Primary tumor 3–4 (vs. 1–2)

2.88

1.58–4.96

 < 0.001

0.85

0.36–2.00

0.711

Tumor number (multiple)

2.75

1.87–4.04

 < 0.001

2.26

1.32–3.88

0.003

Tumor size > 5 cm

1.85

1.31–2.61

 < 0.001

1.51

0.98–2.32

0.059

Fc-inf (yes)

1.39

0.96–2.02

0.085

-

Portal vein invasion (yes)

3.20

1.80–5.70

 < 0.001

1.56

0.66–3.69

0.308

Hepatic vein invasion (yes)

4.23

2.26–7.90

 < 0.001

1.58

0.70–3.52

0.266

IM (yes)

4.07

2.54–6.52

 < 0.001

1.45

0.72–2.90

0.298

Edmondson-Steiner grade 3 or 4 (vs. 1 or 2)

1.44

0.98–2.10

0.060

-

 Fibrosis stage 4 (vs. 0–3) ^a

1.38

0.96–1.99

0.080

-

 Operation time > 480 min

1.55

1.07–2.26

0.022

1.64

1.08–2.49

0.020

 Blood loss > 500 ml

1.17

0.83–1.64

0.370

-

Inflow occlusion time > 60 min

1.21

0.86–1.70

0.284

-

 Non-anatomical resection

0.84

0.59–1.01

0.331

-

 Surgical margin < 1 mm

1.49

1.01–2.21

0.046

0.99

0.63–1.56

0.969

 Major complication ^b

1.78

1.19–2.63

0.005

1.46

0.94–2.26

0.091