Table 6 Recurrence predictors of gastric cancer with and without indication for adjuvant chemotherapy by Cox regression analysis

Univariate analysis

 Age

1.054 (0.974–1.141)

0.193

1.042 (1.005–1.081)

0.026

 Sex (Male)

N.C

1.348 (0.599–3.033)

0.471

 Location (Lower)

N.C

0.816 (0.402–1.656)

0.574

 Surgery (TG)

0.541 (0.065–4.494)

0.570

0.722 (0.346–1.504)

0.384

 Lymph node dissection (D2)

0.553 (0.107–2.853)

0.480

0.760 (0.368–1.570)

0.458

 Synchronous multiple GCs (Yes)

3.551 (0.688–18.330)

0.130

0.455 (0.108–1.919)

0.284

 Macroscopic type (3 + 4)

4.844 (0.582–40.310)

0.144

0.763 (0.376–1.548)

0.453

 Depth of tumor invasion

2.382 (1.084–5.230)

0.031

1.678 (0.945–2.981)

0.077

 Histology (por sig nec)

0.652 (0.127–3.361)

0.609

0.736 (0.316–1.716)

0.478

 Cancer stromal volume (sci)

2.144 (0.393–11.710)

0.379

1.090 (0.537–2.214)

0.811

 Tumor infiltration pattern (INFc)

1.083 (0.210–5.582)

0.924

0.694 (0.336–1.432)

0.322

 VI grade

3.199 (1.624–6.302)

0.001

2.319 (1.497–3.593)

< 0.001

 Lymphatic invasion (Yes)

3.865 (0.865–17.277)

0.077

N.C

 Nodal metastasis

2.664 (1.106–6.415)

0.029

1.370 (0.884–2.125)

0.159

 Resection margin status (R1 + R2)

N.C

2.047 (0.830–5.046)

0.120

 pTNM stage

5.984 (1.338–26.767)

0.019

1.577 (0.646–3.847)

0.317

 Neoadjuvant chemotherapy (Yes)

N.C

0.835 (0.113–6.157)

0.860

 Adjuvant chemotherapy (Yes)

9.875 (2.200–44.334)

0.003

0.315 (0.130–0.760)

0.010

Multivariate analysis

 Age

N.A

1.011 (0.966–1.059)

0.631

 Depth of tumor invasion

N.A

1.581 (0.804–3.107)

0.184

 VI grade

2.688 (1.240–5.825)

0.012

1.918 (1.137–3.237)

0.015

 pTNM stage

2.273 (0.413–12.494)

0.345

N.A

 Adjuvant chemotherapy (Yes)

N.A

0.387 (0.137–1.091)

0.073