Table 5 Clinicopathologic characteristics of gastric cancer with and without indication for adjuvant chemotherapy
Parameters | Without AC indication | With AC indication | ||||
|---|---|---|---|---|---|---|
Recurrence | p value | Recurrence | p value | |||
Yes (n = 7) | No (n = 95) | Yes (n = 31) | No (n = 24) | |||
Age | ||||||
Median (range) | 71 (70–86) | 70 (42–92) | 0.199 | 79 (42–96) | 73 (55–84) | 0.040 |
Sex | ||||||
Male/Female | 7/0 | 63/32 | 0.095 | 23/8 | 18/6 | 1.000 |
Location | ||||||
Upper/Middle/Lower/extending in 2 or 3 regions | 0/0/7/0 | 22/14/56/3 | 0.360 | 6/4/16/5 | 4/5/12/3 | 0.950 |
Surgery | ||||||
DG/TG/others | 6/1/0 | 70/23/2 | 1.000 | 18/12/1 | 10/14/0 | 0.273 |
Lymph node dissection | ||||||
D1/D1+/D2 | 0/5/2 | 8/47/40 | 0.852 | 3/9/19 | 2/7/15 | 1.000 |
Synchronous multiple GCs | ||||||
Yes/No | 2/5 | 9/86 | 0.165 | 2/29 | 4/20 | 0.387 |
Macroscopic type | ||||||
0/1/2/3/4/5 | 3/0/1/0/1/2 | 75/5/8/3/0/4 | 0.774 | 0/4/10/7/9/1 | 0/1/6/7/7/3 | 0.397 |
Histology | ||||||
pap tub1/tub2/muc/por sig nec | 4/1/0/2 | 34/24/0/37 | N.C | 2/4/1/24 | 1/4/0/19 | 1.000 |
Depth of tumor invasion | ||||||
pT1/pT2/pT3 | 3/1/3 | 75/8/12 | 0.229 | 2/12/17 | 4/15/5 | 0.093 |
Cancer stromal volume | ||||||
med /int/sci/not described | 0/4/2/1 | 3/43/10/39 | 0.947 | 0/14/17/0 | 2/11/9/2 | 0.551 |
Tumor infiltration pattern | ||||||
INFa/INFb/INFc/not described | 0/5/2/0 | 3/46/18/28 | 1.000 | 1/11/19/0 | 0/8/15/1 | 1.000 |
VI grade | ||||||
v0/v1/v2/v3 | 1/2/2/2 | 58/27/7/3 | 0.064 | 0/14/8/9 | 6/11/7/0 | 0.012 |
Lymphatic invasion | ||||||
Yes/No | 4/3 | 23/72 | 0.078 | 31/0 | 24/0 | N.C |
Nodal metastasis | ||||||
pN0/pN1/pN2 | 4/2/1 | 87/4/4 | 0.158 | 6/8/17 | 8/6/10 | 0.667 |
Resection margin status | ||||||
R0/R1/R2 | 7/0/0 | 94/1/0 | 1.000 | 25/5/1 | 23/1/0 | 0.591 |
pTNM stage | ||||||
I/II/III | 3/4/0 | 79/16/0 | 0.026 | 0/6/25 | 0/8/16 | 0.350 |
Neoadjuvant chemotherapy | ||||||
Yes/No/unknown | 0/7/0 | 0/83/12 | N.C | 1/28/2 | 1/22/1 | 1.000 |
Adjuvant chemotherapy | ||||||
Yes/No/unknown | 4/3/0 | 9/74/12 | 0.008 | 19/7/5 | 20/3/1 | 0.299 |