Table 3 Recurrence predictors of gastric cancer by Cox regression analysis

Univariate analysis

 Age

1.052 (1.017–1.088)

0.003

 Sex (Male)

1.772 (0.812–3.867)

0.151

 Location (Lower)

1.067 (0.556–2.044)

0.846

 Surgery (TG)

1.196 (0.612–2.338)

0.601

 Lymph node dissection (D2)

1.294 (0.683–2.454)

0.429

 Synchronous multiple GCs (Yes)

1.025 (0.364–2.890)

0.963

 Macroscopic type (3 + 4)

3.577 (1.883–6.796)

< 0.001

 Depth of tumor invasion

2.827 (2.032–3.933)

< 0.001

 Histology (por sig nec)

2.134 (1.076–4.229)

0.030

 Cancer stromal volume (sci)

2.293 (1.203–4.371)

0.012

 Tumor infiltration pattern (INFc)

1.731 (0.913–3.282)

0.093

  *Scirrhous pattern

3.928 (2.077–7.428)

< 0.001

 VI grade

2.967 (2.161–4.072)

< 0.001

 Lymphatic invasion (Yes)

13.902 (4.270–45.262)

< 0.001

 Nodal metastasis

2.404 (1.841–3.139)

< 0.001

 Resection margin status (R1 + R2)

4.619 (1.919–11.120)

0.001

 pTNM stage

4.152 (2.633–6.547)

< 0.001

 Neoadjuvant chemotherapy (Yes)

2.295 (0.314–16.795)

0.413

 Adjuvant chemotherapy (Yes)

4.651 (2.208–9.796)

< 0.001

Multivariate analysis

 Age

1.035 (0.998–1.073)

0.065

 Scirrhous pattern

1.507 (0.729–3.115)

0.269

 VI grade

2.119 (1.439–3.120)

< 0.001

 Resection margin status

0.802 (0.315–2.040)

0.643

 pTNM stage

2.577 (1.496–4.437)

0.001