Table 3 Performance of different cut-offs on three pCLE diagnostic criteria in the blinded validation (CI confidence intervals)
Cut-off | Average Sensitivity, %; (95%CI) | Average Specificity, %; (95%CI) | Average Accuracy, %; (95%CI) | Positive predictive value, %; (95%CI) | Negative predictive value, %; (95%CI) |
|---|---|---|---|---|---|
≥ 1 positive criterion | 80.9 (58.1—94.5) | 70.6 (44.0—89.7) | 76.3 (59.8—88.6) | 77.3 (61.3 – 88.0) | 75.0 (54.1—88.4) |
≥ 2 positive criteria | 66.7 (43.0—85.4) | 82.3 (56.6—96.2) | 73.7 (56.9—86.6) | 82.3 (61.5 -93.2) | 66.7 (51.3—79.2) |
3 positive criteria | 40.0 (19.1—63.9) | 94.44 (72.7—99.9) | 65.79 (48.6—80.4) | 88.9 (52.5 -98.3) | 58.6 (49.3—67.3) |