Table 2 Performance of the four diagnostic criteria in the blinded validation (CI – confidence intervals)
Criterion | Average Sensitivity, %; (95%CI) | Average Specificity, %; (95%CI) | Average Accuracy, %; (95%CI) | Cohen’s Kappa | Positive predictive value, %; (95%CI) | Negative predictive value, %; (95%CI) |
|---|---|---|---|---|---|---|
A. Glands with attenuated margins | 50.0 (31.3–68.7) | 89.3 (71.8–97.7 | 69.0 (55.5–80.5) | 0.277 | 83.3 (61.8–94.0) | 62.5 (53.3–80.5) |
B. Glands with spiculated or irregular shapes | 48.3 (29.4–67.5) | 86.2 (68.3–69.1) | 67.2 (53.7–79.0) | 0.575 | 77.8 (56.7–90.4) | 62.5 (53.2–70.1) |
C. Heterogenous granular stroma with sparse glands | 65.33 (43.9–80.1) | 85.7 (67.3–96.0) | 74.1 (61.0–84.7) | 0.650 | 82.6 (64.8–92.4) | 68.6 (57.1–78.1) |
D. Enlarged vessels with tortous shape and turbulent flow | 20.0 (7.7–38.6) | 89.3 (71.8–98.0) | 53.4 (39.9–66.7) | 0.612 | 66.7 (35.6–87.9) | 51.7 (38.2–65.0) |