Table 1 Characteristics of the study cohort

Age median, years (IQR)

45 (20–67)

Males, n (%)

15 (48.4)

Fentanyl, μg; median (IQR)

75 (50–100)

Midazolam, mg; median (IQR)

5 (4–10)

Endoscopy purpose, n (%)

 - Index

10 (32.2)

 - Surveillance

21 (67.8)

CDH1 pathogenic variant status, n (%)

 - Positive

27 (87.1)

 - Variant of unknown significance

1 (3.2)

 - Negative

3 (9.7)

Previous history of positive signet ring cell carcinoma finding n (%)

15 (48.4)

Ethnicity, n (%)

 - White British

14 (45.2)

 - Other white

9 (29.2)

 - Asian

8 (25.6)

Number of pale areas assessed with pCLE per procedure, median (IQR)

2 (1–5)

Number of control areas assessed with pCLE per procedure, median (IQR)

1 (1–2)

Number of targeted biopsies taken, median (IQR)

5 (2–11)

Pale area location, n (%)

 - pre-pyloric area

1 (1.3)

 - antrum

44 (57.1)

 - t-zone

3 (3.9)

 - body

8 (10.4)

 - fundus

21 (27.3)

Foci of signet ring cell location^a, n (%)

 - pre-pyloric area

0 (0)

 - antrum

16 (72.8)

 - t-zone

0 (0)

 - body

4 (18.1)

 - fundus

2 (9.1)