Fig. 2

Endomicroscopic features of signet-ring cell carcinoma with histopathological correlation based on matched biopsies. A Glands with attenuated margins. The arrows point one of the attenuated margin of one glands. B Glands with spiculated or irregular shapes. The left arrow shows spiculated end of one gland and the right arrow points irregular gland shape. C Heterogenous granular stroma with sparse glands. The arrows show occasional glands with intermixed heterogenous stroma. D Enlarged vessels with tortuous shape and turbulent flow. The arrows show vessels with a visible blood flow (this criterion is best appreciated on a live dynamic view). E Histopathology view on H&E staining (40X) of Criterion A showing a gland with attenuated margins (arrows). F Histopathology view on H&E staining (40X) of Criterion B showing a gland with irregular, spiculated shape (arrows). G Histopathology view on H&E staining (40X) of Criterion C showing small glands spaced away by stroma infiltrated by signet ring cells. H Histopathology view on H&E staining (40X) of Criterion D showing showing blood vessel with irregular shape due to adjacent signet ring cells