Fig. 4

Metabolomics analysis of TFK-1 cell line under PF-04691502 treatment. a OPLS-DA score scatter plot of the TFK-1 cell line under mock and PF-04691502 treatment. b Corresponding S-plot of the TFK-1 cell line under mock and PF-04691502 treatment. The metabolites with absolute value of P(corr)[1] > 0.7 are highlighted with yellow circles. The symbols of P[1] and P(corr)[1] are P values, which represent the contribution to the relative quantities of each metabolite and the difference between groups, respectively. Metabolomics related to pathways of glycolysis and the TCA cycle are shown. c Metabolomics related to pathways of glycolysis and the TCA cycle. Signal intensities of each metabolite measured by GC–MS/MS are shown in the bow-whisker plots. * vs control, P < 0.05, ** vs control, P < 0.001