Table 3 Results of serum markers of HBV and biochemistry in treatment groups
Variables (Time) | Group B (n = 46) | Group C (n = 39) | Group D (n = 32) | P value |
|---|---|---|---|---|
ALT(U/L) | ||||
0 W | 30 (20.5,45.3)a | 21.2(16,32) | 19 (14,27)a | < 0.05 |
12 W | 53(30,83.3)b | 57(35,70)d | 19.5(15,26.8) | < 0.05 |
24 W | 43.5(26.5,61.8) | 50.5(35.3,65.8)d | 19(16,24.8) | < 0.05 |
AST(U/L) | ||||
0 W | 23(19,33) | 21(18,27) | 23(16,26) | 0.375 |
12 W | 40.5(31,59.3)b | 40(32,66)d | 21(17.3,24.9) | < 0.05 |
24 W | 35(26,50.3)b | 46.5(32.3,57)d | 20(18,24.8) | < 0.05 |
TBIL (umol/L) | ||||
0 W | 11.7(9.8,14.6) | 10.9(7.6,15.9) | 11.1(9.6,13.3) | 0.672 |
12 W | 9.9(7.8,13)b | 9.9(8.2,13.1) | 10.9(8.8,13.2) | 0.605 |
24 W | 8.5(6.8,10.4)b | 9.9(8.3,11.8)d | 10.9(8.5,13.0) | < 0.05 |
WBC (×109/L) | ||||
0 W | 5.6(4.9,6.7) | 5.6(4.7,6.4) | 5.6(4.7,6.9) | 1 |
12 W | 3.1(2.6,4.4)b | 3.0(2.6,3.7)d | 5.7(4.7,7.0) | < 0.05 |
24 W | 3.4(2.4,4.5)b | 3.3(2.8,4.0)d | 5.3(4.4,6.0) | < 0.05 |
PLT (×109/L) | ||||
0 W | 185(157,229) | 198(1177,244) | 195(150.8,230.3) | 0.149 |
12 W | 108.5(90.5,148.8)b | 111(86,135)d | 195(150.3,232.8) | < 0.05 |
24 W | 116.5(78.8,164)b | 105.5(91.3,134.5)d | 197.5(155.8,233.8) | < 0.05 |
HBsAg IU/mL | ||||
0 W | 1718.4(675.3,5945.1) | 208.1(46.8,3451.6)c | 2159.7(978.5,8360.6)c | < 0.05 |
12 W | 1335.5(124.0,4081.7)b | 92.9(3.49,1083.2)e | 2254.6(1075.0,8734.4) | < 0.05 |
24 W | 1001.3(10.9,2852.7)b | 48.7(0.98,989.4)d | 1959.5(748.9,7293.0) | < 0.05 |
HBV-DNA (-) | ||||
0 W n (%) | 26(56.5) | 24(61.5) | 19(59.4) | 0.895 |
12 W n (%) | 40(87.0)b | 34(87.2)d | 23(71.9) | 0.151 |
24 W n (%) | 40(87.0)b | 32(82.1)d | 26(56.5) | 0.749 |
Early respond | ||||
Yes n (%) | 27(58.7) | 20(51.3) | 10(31.2) | 0.054 |
No n (%) | 19(41.3) | 19(48.7) | 22(68.8) | |
HBsAg SC n (%) | 4(8.7) | 7(17.9) | 0 |