Fig. 1

TFV + Peg-IFN-α promoted the expression of IL-1β and inhibited HBV replication: Huh7 cells were transfected with HBV 1.3-mer WT and treated with 20µmol/L TFV, 1000 U/mL Peg-IFN-α, and 20 µmol/L TFV + 1000 U/mL Peg-IFN-α for 24h

(a-c) Cells were harvested and subjected to qRT-PCR. (d-f) The levels of supernatant IL-1β, HBsAg, and HBeAg were detected by ELISA. The results are presented as the means ± SD, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001