Table 1 Demographics and clinical characteristics of eligible patients
Characteristics | Total cohort N(%) | Development cohort N (%) | Validation cohort N (%) | P-value |
|---|---|---|---|---|
Number of patients | 3348 | 2344(70%) | 1004(30%) | |
Age | 0.732 | |||
< 45 | 330(9.9%) | 236(10.1%) | 94(9.3%) | |
45–64 | 1613(48.1%) | 1128(48.1%) | 485(48.5%) | |
65–84 | 1234(36.9) | 866(36.9) | 368(36.7%) | |
≥ 85 | 171(5.1%) | 114(5.9%) | 57(5.7%) | |
Sex | 0.396 | |||
Female | 1480(44.2%) | 1025(43.7%) | 455(45.3%) | |
Male | 1868(55.8%) | 1319(56.3%) | 549(54.7%) | |
Race | 0.343 | |||
White | 2623(78.3%) | 1852(79.0%) | 771(76.8%) | |
Black | 292(8.7%) | 202(8.6%) | 90(9.0%) | |
Asian or Pacific Islander | 412(12.3%) | 274(11.8%) | 138(13.7%) | |
American Indian/Alaska Native | 21(0.7%) | 16(0.7%) | 5(0.5%) | |
Marital | 0.513 | |||
Single | 651(19.5%) | 471(20.1%) | 180(17.9%) | |
Married | 1923(57.4%) | 1330(56.7%) | 593(59.1%) | |
Divorced or Separated | 355(10.6%) | 255(10.9%) | 100(10%) | |
Widowed | 404(12.1%) | 278(11.9%) | 126(12.5%) | |
Unmarried or Domestic Partner | 15(0.4%) | 10(0.4%) | 5(0.5%) | |
Radiation | 0.559 | |||
No | 2586(77.2%) | 1817(77.5%) | 769(76.6%) | |
Yes | 762(22.8%) | 527(22.5%) | 235(23.4%) | |
Chemotherapy | 0.204 | |||
No | 968(28.9%) | 693(2936%) | 275(27.4%) | |
Yes | 2380(71.1) | 1651(70.4%) | 729(72.6%) | |
Summary_stage | 0.595 | |||
Regional | 2551(76.2%) | 1780(75.9%) | 771(76.8%) | |
Distant | 797(23.8%) | 564(24.1%) | 233(23.2%) | |
AJCC_Stage | 0.086 | |||
IIIA | 330(9.9%) | 228(9.7%) | 102(10.2) | |
IIIB | 1653(49.3%) | 1168(49.8%) | 485(48.3%) | |
IIIC | 625(18.7%) | 417(17.8%) | 208(20.7%) | |
IVA | 489(14.6%) | 340(14.5%) | 149(14.8%) | |
IVB | 251(7.5%) | 191(8.2%) | 60(6.0%) | |
T | 0.918 | |||
T1 | 66(2.0%) | 47(2.0%) | 19(1.9%) | |
T2 | 351(10.5%) | 244(10.4%) | 107(10.7%) | |
T3 | 2210(66.0%) | 1555(66.3%) | 655(65.2%) | |
T4a | 497(14.8%) | 347(14.8%) | 150(15.0%) | |
T4b | 224(6.7%) | 151(6.5%) | 73(7.2%) | |
N | 0.726 | |||
N1a | 921(27.5%) | 657(28.0%) | 264(26.3%) | |
N1b | 986(29.5%) | 695(29.7%) | 291(29.0%) | |
N1c | 5(0.1%) | 3(0.1%) | 2(0.2%) | |
N2a | 726(21.7%) | 498(21.3%) | 228(22.7%) | |
N2b | 710(21.2%) | 491(20.9%) | 219(21.8%) | |
Tumor_size | 0.924 | |||
≤ 3.7 cm | 849(25.4%) | 590(25.2%) | 259(25.8%) | |
3.8–5.6 cm | 1579(47.1%) | 1107(47.2%) | 472(47.0%) | |
≥ 5.7 cm | 920(27.5%) | 647(27.6%) | 273(27.2%) | |
Regional_nodes_examined | 0.640 | |||
1–12 | 686(20.5%) | 489(21.9%) | 197(19.6%) | |
13–16 | 842(25.1%) | 592(25.3%) | 250(24.9%) | |
≥ 17 | 1820(56.4%) | 1263(53.8%) | 557(55.5%) | |
Regional_nodes_positive | 0.345 | |||
1–3 | 1913(57.1%) | 1358(57.9%) | 555(55.3%) | |
4–8 | 976(29.2%) | 668(28.5%) | 308(30.7%) | |
≤ 9 | 459(13.7%) | 318(13.6%) | 141(14.0%) |