Table 4 Effect estimates of the associations of IBS with phylum Actinobacteria, genus Eisenbergiella and genus Flavonifractor in the reverse MR analyses
Gut microbiome | Methods | N.SNPs | OR | 95% CI | p-value | Intercept p- value |
|---|---|---|---|---|---|---|
Phylum Actinobacteria | Â | Â | Â | Â | Â | Â |
|  | Inverse-variance weighted | 5 | 1.05 | 0.83–1.32 | 0.693 |  |
|  | Weighted median | 5 | 1.02 | 0.77–1.34 | 0.914 |  |
|  | MR-PRESSO test | 5 | 1.05 | 0.91–1.21 | 0.553 |  |
| Â | MR-Egger | 5 | / | / | / | 0.985 |
Genus Eisenbergiella | Â | Â | Â | Â | Â | Â |
|  | Inverse-variance weighted | 5 | 0.80 | 0.53–1.21 | 0.290 |  |
|  | Weighted median | 5 | 0.84 | 0.49–1.44 | 0.528 |  |
|  | MR-PRESSO test | 5 | 0.80 | 0.53–1.21 | 0.288 |  |
| Â | MR-Egger | 5 | / | / | / | 0.191 |
Genus Flavonifractor | Â | Â | Â | Â | Â | Â |
|  | Inverse-variance weighted | 5 | 1.00 | 0.71–1.41 | 0.982 |  |
|  | Weighted median | 5 | 1.16 | 0.79–1.72 | 0.450 |  |
|  | MR-PRESSO test | 5 | 1.00 | 0.70–1.41 | 0.983 |  |
| Â | MR-Egger | 5 | / | / | / | 0.030 |