Peripheral blood T-lymphocyte subsets are potential biomarkers of disease severity and clinical outcomes in patients with ulcerative colitis: a retrospective study

Table 4 Clinical characteristics of UC patients according to clinical outcomes

Variables	UC-related readmission and surgery (n=24)	Non- readmission and non-surgery (n=92)	P value
Sex			0.117
Male	11	59
Female	13	34
Age (years)	42.63±17.72	47.83±16.05	0.169
BMI(kg/m²)	19.24±3.10	22.36±3.28	<0.001^*
Disease duration (months)	50.15±58.81	57.98±64.35	0.590
Smoking history	4(16.67%)	9(9.78%)	0.465
Alcohol consumption history	5(20.83%)	12(13.04%)	0.342
History of appendectomy	1(4.17%)	7(7.61%)	0.690
Extraintestinal manifestations	3(12.50%)	10(10.87%)	0.730
Montreal classification			0.153
E1	0	5
E2	1	16
E3	23	71
Disease severity			<0.001^*
Mild activity	2	35
Moderate activity	3	38
Severe activity	19	19
Treatment			0.105
5-aminosalicylic acid	5	40
Steroids	9	19
Immunosuppressants	1	2
Biological agents	9	31
WBC(×10⁹/L)	7.82±3.55	6.81±2.47	0.107
NE(×10⁹/L)	5.19±3.06	4.29±1.92	0.178
LYM(×10⁹/L)	1.88±0.63	1.90±0.85	0.936
PLT(×10⁹/L)	384.88±105.43	282.96±94.65	<0.001^*
Hb(g/L)	93.92±24.23	118.33±25.29	<0.001^*
Alb(g/L)	29.69±6.59	37.63±5.50	<0.001^*
ESR(mm/60min)	24.18±15.18	19.47±21.37	0.313
CRP(mg/L)	20.15±15.38	11.61±23.06	0.089
CD3⁺T cells (%)	76.71±7.72	74.25±8.30	0.193
CD4⁺T cells (%)	41.47±10.74	43.21±9.53	0.440
CD8⁺T cells (%)	31.19±10.59	27.01±8.20	0.039^*
CD4⁺/CD8⁺ ratio	1.59±0.82	1.80±0.80	0.217
CD4⁺CD25⁺T cells (%)	3.10±1.40	3.15±1.20	0.865
CD3⁺HLA-DR⁺T cells (%)	10.36±9.42	3.88±2.57	0.003^*

UC ulcerative colitis, BMI body mass index, WBC white blood cells, NE neutrophils, LYM lymphocytes, PLT platelets, Hb hemoglobin, Alb albumin, ESR erythrocyte sedimentation rate, CRP C-reactive protein.
^*P<0.05 was considered statistically significant.

ISSN: 1471-230X