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Table 1 Baseline characteristics of ulcerative colitis (UC) patients and healthy controls (HC)

From: Peripheral blood T-lymphocyte subsets are potential biomarkers of disease severity and clinical outcomes in patients with ulcerative colitis: a retrospective study

Characteristics

UC (n=116)

Mild activity (n=37)

Moderate activity (n=41)

Severe activity (n=38)

HC (n=90)

P value a

P value b

P value c

P value d

Sex

     

0.377

0.058

0.674

0.012*

 Male

69

20

31

18

48

    

 Female

47

17

10

20

42

    

Age (years)

46.75±16.47

50.24±13.23

43.27±17.71

47.11±17.54

50.06±10.09

0.077

0.063

0.408

0.300

BMI (kg/m2)

21.71±3.47

23.03±2.42

22.69±3.73

19.38±2.87

25.51±3.39

<0.001*

0.626

<0.001*

<0.001*

Disease duration(months)

56.36±63.08

54.54±61.81

67.87±67.08

45.72±59.33

—

—

0.352

0.545

0.121

Smoking history

13(11.21%)

2(5.41%)

4(9.76%)

7(18.42%)

16(17.78%)

0.179

0.678

0.153

0.338

Alcohol consumption history

17(14.66%)

2(5.41%)

8(19.51%)

7(18.42%)

19(21.11%)

0.226

0.091

0.153

0.902

History of appendectomy

8(6.90%)

2(5.41%)

4(9.76%)

2(5.26%)

1(1.11%)

0.081

0.179

0.978

0.676

Extraintestinal manifestations

13(11.21%)

2(5.41%)

6(14.63%)

5(13.16%)

—

—

0.268

0.430

0.850

Montreal classification

     

—

0.336

<0.001*

0.001*

 E1

5

4

1

0

—

    

 E2

17

7

10

0

—

    

 E3

94

26

30

38

—

    

Treatment

     

—

0.005*

<0.001*

0.035*

 5-aminosalicylic acid

45

23

19

3

—

    

 Steroids

28

1

14

13

—

    

 Immunosuppressants

3

1

1

1

—

    

 Biological agents

40

12

16

12

—

    

WBC (×109/L)

7.02±2.74

5.79±1.61

7.18±2.47

8.03±3.41

5.93±1.44

<0.001*

0.020*

<0.001*

0.153

NE (×109/L)

4.48±2.22

3.36±1.26

4.58±1.93

5.45±2.75

3.10±0.96

<0.001*

0.011*

<0.001*

0.064

LYM (×109/L)

1.89±0.81

1.87±0.59

1.93±0.74

1.88±1.05

2.18±0.60

0.005*

0.765

0.971

0.792

PLT (×109/L)

304.04±105.03

245.41±62.95

302.54±102.42

362.76±110.03

224.19±46.28

<0.001*

0.009*

<0.001*

<0.001*

Hb (g/L)

113.28±26.88

127.35±19.56

120.44±25.61

91.84±20.90

139.20±14.02

<0.001*

0.174

<0.001*

<0.001*

Alb (g/L)

35.99±6.56

40.54±2.90

37.88±5.22

29.51±5.32

40.56±3.00

<0.001*

0.013*

<0.001*

<0.001*

ESR (mm/60min)

20.44±20.28

9.78±8.32

20.09±21.32

31.20±22.06

—

—

0.016*

<0.001*

<0.001*

CRP (mg/L)

13.38±21.91

1.71±1.92

10.95±21.64

27.37±25.27

—

—

0.035

<0.001*

<0.001*

Clinical Outcome

         

readmission and surgery

24(20.69%)

2(5.41%)

3(7.32%)

19(50.00%)

—

—

0.730

<0.001*

<0.001*

  1. UC ulcerative colitis, HC healthy controls, BMI body mass index, WBC white blood cells, NE neutrophils, LYM lymphocytes, PLT platelets, Hb hemoglobin, Alb albumin, ESR erythrocyte sedimentation rate, CRP C-reactive protein.
  2. *P<0.05 was considered statistically significant.
  3. P value a, comparing UC and HC
  4. P value b, comparing mildly active subgroup and moderately active subgroup
  5. P value c, comparing mildly active subgroup and severely active subgroup
  6. P value d, comparing moderately active subgroup and severely active subgroup
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BMC Gastroenterology

ISSN: 1471-230X

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