Table 3 Treatment characteristics among intrahepatic CCA patients by cirrhosis status
From: Cirrhosis in intrahepatic cholangiocarcinoma: prognostic importance and impact on survival
No Cirrhosis (%) | Cirrhosis (%) | P-Value | |
|---|---|---|---|
N (%) | 2592 (71.1) | 1052 (28.9) | NA |
Surgical Intervention Received | 1157 (44.9) | 331 (31.7) | < 0.001 |
Radiation Therapy Received | 444 (17.4) | 182 (17.6) | 0.871 |
Chemotherapy Received | 1319 (52.3) | 453 (44.1) | < 0.001 |
Treatment Status | 0.004 | ||
No Treatment Given | 271 (12.6) | 145 (16.6) | |
Treatment Given | 1876 (87.0) | 722 (82.5) | |
Active Surveillance | (0.5) | (0.9) | |
Days from Diagnosis to First Course Treatment, Median (IQR) | 36 (20–57) | 40 (20–70) | NA |
Days from Diagnosis to First Course Treatment | < 0.001 | ||
Within 30 Days | 828 (40.5) | 279 (38.3) | |
Between 30 and 60 Days | 759 (37.1) | 229 (31.4) | |
Longer than 60 Days | 459 (22.4) | 221 (30.3) | |
Surgery | |||
Days from Diagnosis to First Surgical Procedure, Median (IQR) | 40 (19–71) | 44 (0–93) | NA |
Days from Diagnosis to First Surgical Procedure | 0.002 | ||
Within 30 Days | 452 (38.1) | 141 (41.2) | |
Between 30 and 60 Days | 364 (30.7) | 72 (21.1) | |
Longer than 60 Days | 371 (31.3) | 129 (37.7) | |
Surgical Margins After Resection | < 0.001 | ||
No Residual Tumor | 848 (32.7) | 212 (20.2) | |
Residual Tumor, NOS | 66 (2.6) | 20 (1.9) | |
Microscopic Residual Tumor | 158 (6.1) | 36 (3.4) | |
Macroscopic Residual Tumor | (0.4) | (0.3) | |
Margins Not Evaluable | 36 (1.4) | 30 (2.9) | |
No Primary Site Surgery | 1432 (55.3) | 721 (68.5) | |
Unknown or Not Applicable | 42 (1.6) | 30 (2.9) | |
Reason for No Surgery of Primary Site | < 0.001 | ||
Surgery Performed | 1157 (44.8) | 331 (31.6) | |
Surgery not a Part of the Planned First Treatment | 1240 (48.0) | 590 (56.4) | |
Contraindication Due to Patient Risk Factors | 164 (6.4) | 112 (10.7) | |
Patient Died Prior to Planned or Recommended Surgery | (0.1) | (0.6) | |
Surgery not Performed but Recommended by Physician | (0.0) | (0.3) | |
Patient/Family Member/Guardian Refusal | 14 (0.5) | (0.3) | |
Unknown if Surgery Performed | (0.2) | (0.1) | |
Radiation | |||
Sequencing of Radiation and Surgical Procedures | 0.009 | ||
None | 2367 (92.0) | 988 (94.9) | |
Radiation Therapy Before Surgery | 44 (1.7) | 17 (1.6) | |
Radiation Therapy After Surgery | 159 (6.2) | 36 (3.5) | |
Radiation Therapy Both Before and After Surgery | (0.0) | (0.0) | |
Intraoperative Radiation Therapy | (0.0) | (0.0) | |
Intraoperative Radiation Therapy with Other Therapy Administered Before/After | (0.0) | (0.0) | |
Days from Diagnosis to Radiation Therapy, Median (IQR) | 81 (47–138) | 78 (46–122) | |
Days from Diagnosis to Radiation Therapy | 0.603 | ||
Within 30 Days | 46 (10.6) | 23 (12.9) | |
Between 30 and 60 Days | 112 (25.9) | 41 (22.9) | |
Longer than 60 Days | 275 (63.5) | 115 (64.3) | |
Systemic | |||
Days from Diagnosis to Systemic Therapy, Median (IQR) | 49 (29–82) | 48 (28–83) | NA |
Days from Diagnosis to Systemic Therapy | 0.958 | ||
Within 30 Days | 336 (26.5) | 114 (26.0) | |
Between 30 and 60 Days | 425 (33.5) | 145 (33.1) | |
Longer than 60 Days | 509 (40.1) | 179 (40.9) | |
Chemotherapy Status and Type | < 0.001 | ||
Not Administered | 1202 (47.7) | 574 (55.9) | |
First Course, NOS | 59 (2.3) | 18 (1.8) | |
Single Agent Chemo | 328 (13.0) | 157 (15.3) | |
Multi Agent Chemo | 932 (37.0) | 278 (27.1) | |
Days from Diagnosis to Chemotherapy, Median (IQR) | 49 (29–82) | 48 (28–84) | NA |
Days from Diagnosis to Chemotherapy | 0.934 | ||
Within 30 Days | 336 (26.6) | 115 (26.2) | |
Between 30 and 60 Days | 423 (33.4) | 144 (32.8) | |
Longer than 60 Days | 506 (40.0) | 180 (41.0) | |
Immunotherapy | 0.099 | ||
Not Administered | 1202 (95.3) | 574 (97.0) | |
Yes; First Course Treatment | 59 (4.7) | 18 (3.0) | |
Days from Diagnosis to Immunotherapy, Median (IQR) | 80 (56–184) | 142 (88–147) | NA |
Days from Diagnosis to Immunotherapy | 0.547 | ||
Within 30 Days | (8.3) | (20.0) | |
Between 30 and 60 Days | (25.0) | (0.0) | |
Longer than 60 Days | (66.7) | (80.0) | |
Palliative Care | 0.479 | ||
Yes | 277 (10.7) | 104 (9.9) | |
No | 2315 (89.3) | 947 (90.1) |