Table 2 Disease staging and tumor characteristics among intrahepatic CCA patients by cirrhosis status
From: Cirrhosis in intrahepatic cholangiocarcinoma: prognostic importance and impact on survival
No Cirrhosis (%) | Cirrhosis (%) | P-Value | |
|---|---|---|---|
Diagnosis Year | 0.884 | ||
2004–2010 | 534 (20.6) | 219 (20.8) | |
2011–2017 | 2058 (79.4) | 833 (79.2) | |
Grade | 0.007 | ||
Well differentiated (I) | 132 (8.6) | 69 (12.9) | |
Moderately differentiated (II) | 813 (53.1) | 246 (46.1) | |
Poorly differentiated (III) | 569 (37.2) | 212 (39.7) | |
Undifferentiated (IV) | 17 (1.1) | (1.3) | |
Clinical Stage | 0.410 | ||
0 | (0.0) | (0.1) | |
1 | 552 (28.3) | 223 (28.3) | |
2 | 364 (18.6) | 140 (17.8) | |
3 | 187 (9.6) | 66 (8.4) | |
4 | 851 (43.6) | 357 (45.4) | |
Pathological Stage | 0.013 | ||
0 | (0.5) | (0.0) | |
1 | 295 (28.9) | 77 (30.3) | |
2 | 205 (20.1) | 50 (19.7) | |
3 | 139 (13.6) | 16 (6.3) | |
4 | 378 (37.0) | 111 (43.7) | |
Bone Metastases | 0.280 | ||
None | 835 (94.9) | 321 (93.3) | |
Yes; Distant Bone Metastases | 45 (5.1) | 23 (6.7) | |
Lung Metastases | 0.778 | ||
None | 796 (90.8) | 314 (91.3) | |
Yes; Distant Lung Metastases | 81 (9.2) | 30 (8.7) | |
Other Metastases | 0.939 | ||
None | 793 (90.2) | 310 (90.1) | |
Yes; Distant Metastases | 85 (9.7) | 34 (9.9) | |
Tumor Size | < 0.001 | ||
0–2.4 cm | 205 (10.0) | 122 (15.5) | |
2.5–4.9 cm | 571 (27.8) | 281 (35.8) | |
5.0–8.4 cm | 726 (35.3) | 248 (31.6) | |
Equal to or greater than 8.5 cm | 553 (26.9) | 135 (17.2) | |
Lymphovascular Invasion | 0.001 | ||
Not Present | 606 (63.3) | 179 (74.6) | |
Present | 351 (36.7) | 61 (25.4) |