Table 3 Univariate and Multivariate Cox regression analysis of CSS in stage IB GAC patients in the training cohort

Age

1.03

1.02–1.04

 < 0.001

1.03

1.02–1.04

< 0.001

Gender

 Female

Reference

Reference

 Male

1.34

1.08–1.67

0.008

1.25

1.05–1.57

0.048

Race

 White

Reference

Reference

 Non-White

0.74

0.59–0.92

0.007

1.05

0.83–1.33

0.683

Marital status

 Married

Reference

 Unmarried

1.05

0.85–1.29

0.675

Grade

 I/II

Reference

Reference

 III/IV

0.81

0.66–0.99

0.038

0.97

0.78–1.2

0.777

Pathology

 Non-SRCC

Reference

Reference

 SRCC

0.81

0.6–1.1

0.175

1.23

0.88–1.72

0.218

Primary site

 Cardia

Reference

Reference

 Distal site

0.4

0.31–0.52

 < 0.001

0.33

0.24–0.44

< 0.001

 Middle site

0.51

0.39–0.66

 < 0.001

0.45

0.34–0.59

< 0.001

 Overlapping/NOS

0.74

0.53–1.04

0.088

0.62

0.43–0.88

0.008

Tumor size

 ≤ 2 cm

Reference

Reference

 ≤ 5 cm

1.22

0.96–1.56

0.107

1.16

0.91–1.49

0.226

 > 5 cm

1.01

0.71–1.42

0.97

1.25

0.88–1.77

0.215

 Unknown

1.46

1–2.12

0.048

1.38

0.94–2.01

0.098

RNE

 ≥ 16

Reference

Reference

 1–15

1.55

1.24–1.93

 < 0.001

1.53

1.22–1.92

< 0.001

Stage

 T1N1M0

Reference

Reference

 T2N0M0

0.74

0.6–0.91

0.004

0.7

0.56–0.87

0.001

Chemotherapy

 No

Reference

Reference

 Yes

0.76

0.61–0.94

0.011

0.77

0.6–0.98

0.032