Table 3 Univariate and multivariate analyses for OS in EGC patients with neoadjuvant chemoradiotherapy

Age

 ≤ 60

Reference

Reference

 > 60

1.171

1.030–1.332

0.016

1.197

1.051–1.363

0.007

Year of diagnosis

 2006–2011

Reference

Reference

 2012–2017

0.894

0.786–1.017

0.088

0.878

0.769–1.001

0.051

Sex

 Male

Reference

Reference

 Female

0.766

0.636–0.923

0.005

0.768

0.636–0.928

0.006

Race

 White

Reference

Reference

 Black

0.722

0.485–1.074

0.108

0.768

0.513–1.150

0.200

 Others

0.794

0.587–1.075

0.136

0.853

0.629–1.158

0.309

Grade

 Well/moderately differentiated

Reference

Reference

 Poorly differentiated/undifferentiated

1.360

1.190–1.553

 < 0.001

1.331

1.158–1.530

 < 0.001

 Others

0.863

0.674–1.105

0.244

0.872

0.680–1.117

0.278

Histology

 Adenocarcinomas

Reference

Reference

 Others

1.179

0.996–1.395

0.056

1.017

0.853–1.212

0.854

Marital status

 Married

Reference

Reference

 Others

1.212

1.058–1.390

0.006

1.296

1.129–1.488

 < 0.001

T-category

 T1

Reference

Reference

 T2

1.418

1.111–1.809

0.005

1.165

0.906–1.499

0.233

 T3

1.347

1.042–1.741

0.023

1.088

0.834–1.418

0.534

 T4

1.977

1.335–2.926

0.001

1.451

0.968–2.175

0.072

N-category

 N0

Reference

Reference

 N1

1.538

1.329–1.779

 < 0.001

1.530

1.315–1.780

 < 0.001

 N2

1.853

1.462–2.349

 < 0.001

1.951

1.527–2.494

 < 0.001

 N3

2.994

1.951–4.593

 < 0.001

2.821

1.824–4.363

 < 0.001

No. of LN examination

 1–9

Reference

Reference

 10–19

0.786

0.676–0.913

0.002

0.758

0.651–0.882

 < 0.001

 > 19

0.736

0.622–0.871

 < 0.001

0.672

0.566–0.797

 < 0.001