Fig. 1

Impact of symptoms of anxiety/depression on UC patients. A Comparison of IBDQ scores, FSS scores, PSQI scores and Compass-31 scores between UC (n = 32) and UD (n = 28) patients; B the relationship between the disease activity (Mayo score, UCEIS, Goboes score) of the two groups and the scores of hospital anxiety and depression scale. C Comparison of proinflammatory cytokines, IL-1β, IL-6 and TNF-α, and anti-inflammatory cytokines, TGF-β1, IL-10, between UC (n = 22) and UD (n = 28) patients. UC: UC patients without symptoms of anxiety/depression; UD: UC patients with symptoms of anxiety/depression; IBDQ: Inflammatory bowel disease questionnaire; FSS: Fatigue severity Scale; PSQI: Pittsburgh Sleep Quality Index; Compass-31: Composite Autonomic symptom score-31; *P < 0.05, ***P < 0.001, ****P < 0.0001