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Fig. 2 | BMC Gastroenterology

Fig. 2

From: Comprehensive analysis of the biological function and immune infiltration of SLC38A2 in gastric cancer

Fig. 2

Tumor-promoting effects of SLC39A2 in GC cells. (A) Representative images of colony formation induced by sh-NC, sh1- SLC38A2 and sh2- SLC38A2 in MKN45 and HGC27 cell lines (**P < 0.01, ***P < 0.001). (B) CCK8 assay was used to compare cell viability in MKN45 and HGC27 cells with SLC38A2 knockdown (***P < 0.001). (C) A cell wound-healing assay showed that cell motility was decreased after SLC38A2 knockdown in the MKN45 and HGC27 cell lines (**P < 0.01, ***P < 0.001). (D) Cell invasion assays of sh-NC, sh1- SLC38A2 and sh2- SLC38A2 in MKN45 and HGC27 cell lines (***P < 0.001). (E) Representative images of nude mouse xenograft tumors. Statistical analysis of xenograft tumor sizes revealed that tumor growth was markedly inhibited by SLC38A2 silencing (***P < 0.001)

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BMC Gastroenterology

ISSN: 1471-230X

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