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Table 3 Cox proportional-hazard regression model analysis for OS

From: Prognostic significance of serum CA125 in the overall management for patients with gastrointestinal stromal tumors

Factors

Univariate analysis OS

Multivariate analysis OS

HR (95%CI)

P value

HR (95%CI)

P value

Age

    

 < 65

    

 ≥ 65

1.861 (1.009–3.432)

0.047

2.286 (1.215–4.303)

0.010

Gender

    

 Male

    

 Female

0.634 (0.340–1.181)

0.151

  

Hemorrhage

    

 No

    

 Yes

0.938 (0.480–1.832)

0.851

  

Rupture

    

 No

    

 Yes

1.987 (0.479–8.241)

0.344

  

Resection style

    

 Complete resection

    

 Incomplete resection

9.217 (4.471–19.003)

< 0.001

5.546 (2.558–12.024)

< 0.001

Tumor site

    

 Stomach

    

 Non-stomach

3.532 (1.893–6.589)

< 0.001

2.115 (1.092–4.096)

0.026

Tumor size

    

 < 5 cm

    

 ≥ 5 cm

3.393 (1.702–6.764)

0.001

0.987 (0.414–2.356)

0.977

Mitotic index

    

 < 5/HPF

    

 ≥ 5/HPF

2.168 (1.183–3.974)

0.012

0.797 (0.397–1.602)

0.524

NIH risk grade

    

 Extremely low or low

    

 Moderate or high

6.220 (2.441–15.847)

< 0.001

4.289 (1.623–11.332)

0.003

c-kit exons

    

 Negative

    

 Positive

1.208 (0.650–2.246)

0.550

  

PDGFRA exons

    

 Negative

    

 Positive

1.355 (0.483–3.797)

0.564

  

Preoperative CA125 level

    

 Normal

    

 High

2.812 (1.382–5.723)

0.004

0.894 (0.292–2.737)

0.844

Increased CA125 level both preoperative and postoperative

    

 No

    

 Yes

5.560 (2.341–13.204)

< 0.001

2.293 (0.931–5.651)

0.071