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Table 2 Cox proportional-hazard regression model analysis for PFS

From: Prognostic significance of serum CA125 in the overall management for patients with gastrointestinal stromal tumors

Factors

Univariate analysis PFS

Multivariate analysis PFS

HR (95%CI)

P value

HR (95%CI)

P value

Age

    

 < 65

    

 ≥ 65

0.586 (0.257–1.339)

0.205

  

Gender

    

 Male

    

 Female

0.750 (0.387–1.456)

0.395

  

Hemorrhage

    

 No

    

 Yes

1.307 (0.662–2.579)

0.441

  

Rupture

    

 No

    

 Yes

1.157 (0.158–8.458)

0.886

  

Resection style

    

 Complete resection

    

 Incomplete resection

8.253 (3.561–19.044)

< 0.001

5.536 (2.298–13.339)

< 0.001

Tumor site

    

 Stomach

    

 Non-stomach

2.516 (1.305–4.849)

0.006

1.599 (0.788–3.243)

0.194

Tumor size

    

 < 5 cm

    

 ≥ 5 cm

1.937 (0.986–3.803)

0.055

  

Mitotic index

    

 < 5/HPF

    

 ≥ 5/HPF

3.820 (1.930–7.561)

< 0.001

2.833 (1.381–5.811)

0.005

NIH risk grade

    

 Extremely low or low

    

 Moderate or high

4.412 (1.831–10.630)

0.001

1.954 (0.658–5.806)

0.228

c-kit exons

    

 Negative

    

 Positive

1.901 (0.978 –3.696)

0.058

  

PDGFRA exons

    

 Negative

    

 Positive

0.739 (0.178–3.079)

0.678

  

Preoperative CA125 level

    

 Normal

    

 High

2.268 (0.992–5.183)

0.052

0.334 (0.076–1.475)

0.148

Increased CA125 level both preoperative and postoperative

    

 No

    

 Yes

6.616 (2.571–17.024)

< 0.001

5.884 (2.257–15.341)

< 0.001