Table 1 Participant selection criteria

• Clinical diagnosis of PSC according to generally accepted criteria [25]

• Age ≥ 18 years

• Sufficient oral and written German language proficiency

• Informed consent

• Advanced cirrhosis (defined by Child Pugh A score ≥ 8) or decompensated liver disease

• History or presence of other concomitant liver disease (especially autoimmune hepatitis or chronic viral hepatitis B or C)

• Presence of clinically significant untreated intercurrent medical condition associated with fatigue (i.e. hypothyroidism, anaemia, fibromyalgia, rheumatoid arthritis, systemic lupus erythematosus, active IBD and manifest depression)

• Serious illness requiring immediate intervention

• Florid psychosis

• Substance abuse disorder

• Acute suicidality