Skip to main content

Table 3 The associations between TSH levels and MAFLD, as well as the FIB-4 and NFS values in patients with FLD

From: Low thyroid function is associated with an increased risk of advanced fibrosis in patients with metabolic dysfunction-associated fatty liver disease

 

Low thyroid function

Low thyroid function

Low-nornal

SCH

OR (95% CI)

P Value

OR (95% CI)

P Value

OR (95% CI)

P Value

Non-MAFLD

Ref

Ref

Ref

MAFLD

Model 1

1.02 (0.95, 1.10)

0.508

1.02 (0.95, 1.10)

0.549

1.03 (0.88, 1.20)

0.725

Model 2

1.08 (1.00, 1.16)

0.043

1.09 (1.01, 1.18)

0.028

1.03 (0.87, 1.22)

0.702

Model 3

1.01 (0.92, 1.11)

0.803

1.02 (0.93, 1.12)

0.690

0.99 (0.81, 1.20)

0.921

FIB-4 ≤ 1.30

 

Ref

 

Ref

 

Ref

 

FIB-4 > 1.30

Model 1

1.60 (1.41, 1.81)

1.84e−13

1.45 (1.27, 1.66)

5.37e−08

2.59 (1.99, 3.39)

2.26e−12

Model 2

1.00 (0.83, 1.19)

0.964

0.95 (0.79, 1.16)

0.632

1.23 (0.83, 1.83)

0.295

Model 3

0.99 (0.83, 1.19)

0.943

0.95 (0.78, 1.15)

0.597

1.25 (0.85, 1.85)

0.266

FIB-4 > 2.67

Model 1

1.98 (1.50, 2.59)

7.85e−07

1.95 (1.46, 2.59)

4.97e−06

2.11 (1.19, 3.51)

0.006

Model 2

1.31 (0.97, 1.77)

0.074

1.41 (1.02, 1.93)

0.033

0.92 (0.50, 1.63)

0.795

Model 3

1.32 (0.97, 1.78)

0.072

1.41 (1.02, 1.93)

0.035

0.95 (0.51, 1.68)

0.874

NFS ≤ − 1.455

Ref

Ref

Ref

NFS > − 1.455

Model 1

1.52 (1.33, 1.73)

4.44e−10

1.41 (1.23, 1.62)

1.54e−06

2.15 (1.63, 2.81)

3.13e−08

Model 2

0.97 (0.81, 1.16)

0.745

0.97 (0.80, 1.18)

0.781

0.98 (0.67, 1.42)

0.904

Model 3

0.92 (0.76, 1.13)

0.439

0.94 (0.76, 1.17)

0.595

0.86 (0.57, 1.28)

0.447

NFS > 0.676

Model 1

2.13 (1.46, 3.09)

7.47e−05

2.18 (1.46, 3.22)

9.76e−05

1.88 (0.78, 3.86)

0.119

Model 2

1.41 (0.93, 2.10)

0.100

1.57 (1.02, 2.39)

0.036

0.79 (0.31, 1.75)

0.594

Model 3

1.52 (0.97, 2.37)

0.065

1.72 (1.08, 2.72)

0.022

0.78 (0.29, 1.84)

0.592

  1. FIB-4 Fibrosis-4 index; MAFLD Metabolic dysfunction-associated fatty liver disease; NFS Non-alcoholic fatty hepatic fibrosis score, TSH Thyroid-stimulating hormone; SCH Subclinical hypothyroidism
  2. Thyroid Function: Strict-normal, TSH 0.4–2.5 mIU/L; low thyroid function: TSH ≥ 2.5 mIU/L; low-normal, TSH 2.5–4.5 mIU/L; subclinical hypothyroidism, TSH > 4.5
  3. Model 1 is a univariable regression model; model 2 is adjusted for age and sex; model 3 additionally adjusted for body mass index, type 2 diabetes, and hypertension
Back to article page

BMC Gastroenterology

ISSN: 1471-230X

Contact us