Evaluating the predictive performance of gut microbiota for the early-stage colorectal cancer

BMC Gastroenterology

Table 2. Estimated accuracy measures of S. bovis and F. nucleatum based on Bayesian bivariate models in the presence and absence of gold standard test outcomes

		Mean	SD	MC error	2.5%	97.5%
Absence of GS test
F. nucleatum
	Sensitivity	0.90	0.11	0.007	0.85	0.97
	Specificity	0.87	0.27	0.001	0.79	0.94
	AUC	0.88	0.08	0.005	0.81	0.96
	Cut-off	<94	-	-	-	-
S. bovis
	Sensitivity	0.93	0.09	0.001	0.84	0.98
	Specificity	0.88	0.33	0.002	0.78	0.93
	AUC	0.91	0.08	0.004	0.83	0.99
	Cut-off	<64	-	-	-	-
\(\rho_{{D^{ + } }}\)		0.76	0.19	0.03	0.64	0.85
\(\rho_{{D^{ - } }}\)		0.68	0.10	0.03	0.51	0.73
Difference		- 0.03	0.14	0.008	- 0.27	0.16
Presence of GS test
F. nucleatum
	Sensitivity	0.91	0.07	0.001	0.85	0.97
	Specificity	0.85	0.04	0.006	0.77	0.91
	AUC	0.87	0.01	0.002	0.78	0.91
	Cut-off	< 135	-	-	-	-
S. bovis
	Sensitivity	0.93	0.10	0.003	0.80	0.99
	Specificity	0.89	0.11	0.003	0.73	0.95
	AUC	0.93	0.03	0.001	0.84	0.98
	Cut-off	< 29	-	-	-	-
\(\rho_{{D^{ + } }}\)		0.69	0.11	0.004	0.58	0.82
\(\rho_{{D^{ - } }}\)		0.64	0.11	0.003	0.54	0.76
Difference		- 0.07	0.03	0.001	- 0.14	- 0.04

SD Standard deviation; MC Monte carlo; F. nucleatum Fusobacterium nucleatum; S. bovis Streptococcus bovis; GS Gold standard; AUC Area under the receiver operating characteristic curve

ISSN: 1471-230X