Fig. 2

a–c Cox regression model entering mucosal TNF gene expression normalization after first anti-TNF treatment and age at inclusion. a Model P = 0.003; low TNF at IFX discontinuation: HR 0.12 (0.01–0.91) for surgery (P = 0.04); Age baseline HR 1.06 (1.01–1.12) for surgery (P = 0.015), b Model P = 0.005; low TNF: HR 0.31 (0.13–0.76) for long-term remission (P = 0.01); c Model P = 0.001; low TNF: HR 0.13 (0.013–0.61) for biological free remission (P = 0.009). HR hazard ratio, IFX infliximab, TNF tumour necrosis factor