Table 1 Definitions of functional dyspepsia according to the Rome IV criteria and the Reference Standard

General definition

In the past three months, with symptom onset six months before diagnosis:

Rome IV-defined PDS;

AND/OR

Rome IV-defined EPS

In the past month, with one of the following symptoms (at least once per week):

Postprandial fullness;

Early satiety;

Epigastric pain;

OR

Epigastric burning

AND

No evidence of organic upper gastrointestinal disease that is likely to explain the symptoms

Postprandial distress syndrome (PDS)

At least three days per week:

Bothersome postprandial fullness;

OR

Bothersome early satiety

At least once per week:

Any degree of postprandial fullness;

OR

Any degree of early satiety

Epigastric pain syndrome (EPS)

At least one days per week:

Bothersome epigastric pain;

OR

Bothersome epigastric burning

At least once per week:

Any degree of epigastric pain;

OR

Any degree of epigastric burning